Imaging and modeling blood flow in perforator flaps for reconstructive surgery
Official title: Study and Modeling of Perforator Flap Vascularization
Run by University Hospital, Montpellier · NCT07084740 · Data updated 2026-11-12
This trial tests PeriCam and PeriFlux imaging to map blood flow in skin and fat flaps used for reconstruction in adults with pelvic eschar or traumatic limb injuries.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University Hospital, Montpellier Academic / other |
| Locations | 1 site (Montpellier) |
| Status | Recruiting |
| Started | February 15, 2026 |
| Main results expected | July 15, 2026 |
| Study ends | July 15, 2026 |
| Registry record updated | April 13, 2026 |
| Trial ID | NCT07084740 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–70 undergoing reconstructive surgery with a pedicled or free perforator flap of at least 50 cm2 for pelvic eschar or traumatic limb pathology, who can give consent and have social security coverage, are ideal candidates.
✕Probably not a fit
People outside the 18–70 age range, those receiving smaller flaps (<50 cm2) or different reconstruction techniques, and those who cannot consent or lack required social coverage are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The project uses noninvasive perfusion imaging (PeriCam and PeriFlux) during reconstructive operations to record blood flow patterns across pedicled and free perforator flaps with surface area ≥50 cm2. Data from patients with pelvic eschar (pedicled flaps) and traumatic lower/upper limb injuries (free flaps) will be collected to build models of vascular territories (perforasomes) and perfusion behavior. Measurements are performed at the time of surgery at University Hospital Montpellier to generate perfusion maps and quantitative parameters. The goal is to improve understanding of flap vascularization beyond cadaveric studies by using live human perfusion data.
Why it matters
Potential benefit: If successful, the work could help surgeons better predict which parts of a flap will stay healthy and reduce flap failure or unnecessary muscle harvest.
How similar studies have gone: Previous clinical and experimental work using perfusion imaging and the perforasome concept has shown promise for predicting flap viability, so this project builds on existing approaches rather than introducing an entirely untested idea.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 70 * Reconstructive surgery using pedicled perforating flap or free perforating flap. * Flap with a surface area of at least 50 cm2 (in order to have a sufficiently large surface area for good perfusion visualization) * Pedicled perforating flaps group: Patients with pelvic eschar * Free perforating flaps group: Traumatic pathology of the lower and/or upper limb Exclusion Criteria: * No consent obtained * No social security affiliation * Persons under court protection * Persons participating in another study with an exclusion period still in progress
Where it's running
-
University Hospital Montpellier
Montpellier, France Recruiting
Study contacts
- Principal investigator: Christian HERLIN, MD, PhD — University Hospital, Montpellier
- Study coordinator: Christian HERLIN, MD, PhD
- Email: c-herlin@chu-montpellier.fr
- Phone: +33467330589
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.