Image collection for early upper gastrointestinal cancer and precancerous conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational effort will gather magnetically-controlled capsule endoscopy (MCE) images, esophagogastroduodenoscopy (EGD) images, CT scans, and corresponding histopathology results from patients undergoing ESD or biopsy for early upper gastrointestinal cancer and precancerous lesions/conditions. Collected images and pathology will be linked and curated to form a standardized database suitable for training and validating image-based deep learning models. Participants must be adults able to consent and tolerate the procedures; standard exclusions apply for capsule retention risk, implanted electromedical devices, pregnancy, and relevant allergies. The work is being conducted at Changhai Hospital and aims to address the current scarcity of MCE image datasets.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male or female participants aged ≥ 18 years
2. Patients with early upper gastrointestinal cancer referred for endoscopic submucosal dissection (ESD), or patients with upper gastrointestinal precancerous lesions or precancerous conditions referred for biopsy by esophagogastroduodenoscopy (EGD)
3. Participants who are willing and able to participate in this study, complete all required examinations and follow-up visits, and who have provided written informed consent

Exclusion Criteria:

1. Patients who are not eligible for surgery or who refuse any abdominal surgery in case of capsule retention and endoscopic retrieval failure
2. Patients with cardiac pacemaker or other implanted electromedical devices which could interfere with magnetic resonance
3. Suspected or known intestinal stenosis or other known risk factors for capsule retention
4. Patients with dysphagia
5. Pregnancy
6. Allergy to polymeric materials, latex, simethicone, or pronase
7. Patients plan to undergo magnetic resonance imaging examination before excretion of the capsule
8. Patients with any condition that precludes compliance with the study

Where it's running

• Changhai Hosptial
  Shanghai, China Recruiting

Study contacts

• Principal investigator: Jun Pan, MD — Changhai Hospital
• Study coordinator: Jun Pan, MD
• Email: panjun059@163.com
• Phone: +86-13764598567

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.