Identifying tumor molecules for early pancreatic cancer detection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to improve the early detection of pancreatic cancer by investigating various tumor regulatory molecules. The focus is on identifying markers that can signal the presence of pancreatic cancer or pre-cancerous cysts, which are often difficult to diagnose due to a lack of specific symptoms. By studying these molecules, the researchers hope to develop a less invasive and more effective screening method that could lead to earlier surgical intervention and better patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

General

* Capable of giving written informed consent
* Age ≥18 years

Pancreatic Cancer Cohort

\- Diagnosed with localised pancreatic cancer amenable to resection (distal pancreatectomy, total pancreatectomy or Whipple's procedure).

OR - Diagnosed with inoperable localised pancreatic cancer and referred for further management (malignant control subgroup).

Pancreatic Cysts Cohort

\- Presence of cystic lesions where MDT have agreed further diagnostic intervention procedures (including FNA/EUS) necessary.

OR - Patient the MDT have agreed have resectable lesions suspicious for pancreatic malignancy and going to surgery.

Benign Cohort

\- Referral for endoscopic cystogastrostomy for complicated acute pancreatitis characterised by peripancreatic fluid collections and pseudocysts in development or matured (non-resolving and requiring further intervention).

OR

* Referral for cholecystectomy for cholocystitis/chololethiasis. OR
* Patient planned to have endoscopy investigation for dyspepsia (normal control subgroup).

Exclusion Criteria:

General

* Inability to provide written informed consent
* Other known malignant condition, either active or in complete remission ≤5 years
* HIV, hepatitis C, or any other known communicable disease

Where it's running

• Castle Hill Hospital, Hull University Teaching Hospitals NHS Trust
  Cottingham, Kingston Upon Hull, United Kingdom Recruiting

Study contacts

• Principal investigator: Anthony Maraveyas — Hull University Teaching Hospitals NHS Trust
• Study coordinator: Anthony Maraveyas
• Email: anthony.maraveyas@nhs.net
• Phone: 01482 461245

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Liquid biopsy biomarkers to detect and monitor pancreatic cancer

  Researchers test blood-based microRNA signals to see if they can identify pancreatic cancer risk or early disease in people with familial or hereditary risk or mucinous cysts.

  Recruiting Università Vita-Salute San Raffaele · Milan, MI · NCT07700992

• Registry of images and videos from endoscopic procedures for pancreatic diseases

  This study is collecting images and videos from endoscopic procedures on patients with pancreatic diseases to help improve how these conditions are understood and treated.

  Recruiting IRCCS San Raffaele · Milan · NCT06344507

• Using cell-free DNA to diagnose pancreatic cancer

  This study is testing whether a new blood test that looks at cell-free DNA can help diagnose pancreatic cancer earlier and more easily than current methods.

  Recruiting University of Central Florida · Orlando, Florida · NCT06148298

• Using technology to improve care for pancreatic cancer patients

  This study is trying to see if sharing patient data among hospitals can help improve care and outcomes for people with pancreatic cancer.

  Recruiting UMC Utrecht · Utrecht · NCT06055010

• Evaluating Gemcitabine chemotherapy for metastatic pancreatic cancer patients with the GemCore signature

  This study is testing if Gemcitabine chemotherapy can help people with advanced pancreatic cancer who have a specific marker in their tumors.

  Recruiting Institut Paoli-Calmettes · Marseille · NCT06046794

• Registry collecting radiological data on pancreatic cancer

  This study is collecting medical imaging data from patients with pancreatic cancer to see how their condition progresses and how well they respond to treatment.

  Recruiting IRCCS San Raffaele · Milan · NCT05714111

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.