Identifying triggers for acute ischemic stroke caused by large vessel occlusion
Triggers of Acute Ischemic Stroke Due to Large Vessel Occlusion: A Case-crossover Study
This study looks at what might trigger a stroke caused by a blocked blood vessel by asking patients about their experiences right before the stroke happened.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 302 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Suzhou Municipal Hospital of Anhui Province Academic / other |
| Locations | 1 site (Suzhou, Anhui) |
| Trial ID | NCT06265155 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the short-term risk factors that trigger acute ischemic stroke due to large vessel occlusion. Using a case-crossover design, patients will report their exposure to various potential triggers over the past year, particularly focusing on the period immediately before the onset of stroke. The study will assess the relative risk of ischemic stroke associated with these triggers, including infections and extreme temperature changes. By comparing exposure during high-risk periods to usual exposure frequencies, the study seeks to provide insights into the immediate causes of stroke.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have been diagnosed with large vessel occlusion and have no contraindications for participation.
Not a fit: Patients with severe bleeding tendencies, significant organ dysfunction, or a life expectancy of less than 90 days may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify specific triggers that lead to acute ischemic strokes, potentially guiding preventive strategies for at-risk patients.
How similar studies have performed: While there have been studies on stroke triggers, this specific case-crossover approach focusing on large vessel occlusion is relatively novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. age ≥ 18 years 2. imaging diagnosis of large vessel occlusion 3. CT excluded intracranial hemorrhage 4. signed informed consent form by the patient himself or his legal representative Exclusion Criteria: 1. severe bleeding or known significant bleeding tendency 2. severe organ dysfunction 3. life expectancy of less than 90 days 4. presence of other conditions that the investigator considers inappropriate for enrollment
Where this trial is running
Suzhou, Anhui
- Suzhou Hospital Anhui Medical University — Suzhou, Anhui, China (Recruiting)
Study contacts
- Study coordinator: Anzhi Li, B.S.
- Email: 365819805@qq.com
- Phone: +8615903860581
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.