Identifying RNA biomarkers in patients with acute coronary syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate circulating RNA transcripts in patients with acute coronary syndrome (ACS) who are undergoing percutaneous coronary intervention (PCI). It focuses on identifying specific mRNAs and non-coding RNAs that may predict the risk of ventricular dysfunction following ACS. By analyzing whole genome transcriptomic data from blood samples, the study seeks to establish a signature of biomarkers that could indicate the likelihood of developing heart complications. The findings could enhance prognostic assessments and guide treatment decisions for ACS patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age \>18 years
2. Patients with ACS (first episode), defined according to the guidelines of the European Society of Cardiology (ESC) 2017
3. Indication for percutaneous revascularization treatment
4. Informed consent to study enrollment

Exclusion Criteria:

1. Severe valve disease or other conditions requiring cardiac surgery
2. Previous cardiac surgery including coronary artery bypass grafts
3. Total chronic occlusions
4. Patients with known hypersensitivity or contraindication to any of the following drugs:

   * heparin
   * aspirin,
   * clopidogrel,
   * ticlopidine,
   * sirolimus,
   * everolimus.
5. Any contraindication to drug-eluting stent implantation (DES)
6. Patients with a documented history of myocardial infarction;
7. Left ventricular ejection fraction (LVEF) \<30% before PCI
8. Patients in cardiogenic shock
9. Patients with advanced ST-segment elevation myocardial infarction (\> 48 h from onset of symptoms/Q waves on electrocardiogram) or undergoing fibrinolysis;
10. Patients with prior known cardiomyopathy with LVEF \< 40%
11. Patients with malignant neoplasm or systemic disease with quoad vitam prognosis less than 1 year;
12. Patients with known active infectious diseases;
13. Patients who are unable to express valid informed consent to the act of enlistment
14. Pregnant women

Where it's running

• IRCCS Policlinico S. Donato, Milan, Italy
  Milan, Milan, Italy Recruiting

Study contacts

• Study coordinator: Luca Testa
• Email: luca.testa@grupposandonato.it
• Phone: 0252774987

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.