Identifying risk factors for placenta accreta in women without prior cesarean sections
Risk Factors, Prognosis and Prediction Models for Placenta Accreta Without Prior Cesarean Section：A Prospective Cohort Study
Peking University Third Hospital · NCT06383923
This study is trying to find out what factors might lead to placenta accreta in pregnant women who haven't had a C-section before, to help improve their care and outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Sex | Female |
| Sponsor | Peking University Third Hospital (other) |
| Locations | 1 site (Beijing) |
| Trial ID | NCT06383923 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify risk factors and prognostic indicators for placenta accreta spectrum (PAS) disorders in pregnant women who have not had a prior cesarean section. It will analyze biological samples to investigate the uterine immune microenvironment and its effects on uterine spiral artery remodeling. The study seeks to establish a prediction model to improve the management and outcomes for these patients. By focusing on a cohort that represents a significant portion of the PAS population, the research addresses a critical gap in current clinical understanding and practice.
Who should consider this trial
Good fit: Ideal candidates for this study are pregnant women without a history of cesarean section who are receiving prenatal care at the participating hospital.
Not a fit: Patients who have had a cesarean section or those who give birth before 28 weeks of gestation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved identification and management of placenta accreta in women without prior cesarean sections, potentially reducing complications and improving maternal outcomes.
How similar studies have performed: While there is limited research specifically targeting PAS in women without prior cesarean sections, the study's approach is novel and aims to fill a significant gap in existing literature.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pregnant women without prior cesarean section * Pregnant women who had prenatal check-ups and gave birth at the Obstetrics Department of Peking University Third Hospital from January 1, 2023 to December 31, 2024 Exclusion Criteria: * Pregnant women who did not terminate pregnancy at the Obstetrics Department of Peking University Third Hospital * Pregnant women who gave birth at \<28 weeks.
Where this trial is running
Beijing
- Peking University Third Hospital — Beijing, China (RECRUITING)
Study contacts
- Study coordinator: Wang Yan, M.D.Ph.D.
- Email: wjgqhn@263.net
- Phone: 13501282029
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Placenta Accreta Spectrum