Identifying risk factors for melanoma in young people
Identification of Risk Factors, Exposomics and Genetic Susceptibility of Melanoma in Children, Adolescents and Young Adults - Novel Health Care Strategies for Melanoma in Children, Adolescents and Young Adults (MELCAYA)
This study is trying to find out what environmental and genetic factors increase the risk of melanoma in kids and young adults to help improve prevention strategies.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | N/A to 30 Years |
| Sex | All |
| Sponsor | University Hospital Tuebingen Academic / other |
| Locations | 6 sites (Düsseldorf and 5 other locations) |
| Trial ID | NCT06680323 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify environmental and genetic factors that contribute to the risk and progression of melanoma in children, adolescents, and young adults. By collecting data from various epidemiological and clinical registries across Europe, the study seeks to create a large dataset for comprehensive analysis. It will integrate genetic information with environmental data, such as climate and pollution, to develop a weighted risk score. Additionally, the study will analyze germline mutations and perform genome and transcriptome sequencing to enhance understanding of melanoma etiology and inform prevention strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 30 years or younger who have a confirmed diagnosis of melanoma.
Not a fit: Patients without available biological material or those who do not provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved primary prevention strategies for melanoma in young individuals.
How similar studies have performed: Other studies have shown success in identifying risk factors for melanoma, but this approach of integrating exposomic data with genetic analysis is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * confirmed melanoma * age until 30 years old Exclusion Criteria: * no available biological material * no signed informed consent
Where this trial is running
Düsseldorf and 5 other locations
- Leibniz Research Institute for Environmental Medicine — Düsseldorf, Germany (Active_not_recruiting)
- University of Florence — Florence, Italy (Active_not_recruiting)
- Istituto Nazionale del Tumori — Milan, Italy (Active_not_recruiting)
- Medical University of Gdánsk — Gdansk, Poland (Recruiting)
- Hospital Clínic de Barcelona — Barcelona, Spain (Recruiting)
- Karolinska Institute — Solna, Sweden (Recruiting)
Study contacts
- Study coordinator: Ines B Brecht, MD, PhD
- Email: ines.brecht@med.uni-tuebingen.de
- Phone: +49707183773
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.