Identifying risk factors for brain recurrence in HER2-positive breast cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify risk factors associated with brain recurrence in patients diagnosed with HER2-positive localized breast cancer. It focuses on understanding the incidence of brain metastases in this patient population, particularly in relation to their treatment history and tumor characteristics. The study involves pre-treatment biopsies to gather necessary data for analysis. By examining these factors, the research seeks to improve prognostic assessments and treatment strategies for affected patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years old
* be a female patient
* Patients with histologically proven HER2-positive invasive breast cancer (IHC 3+ or 2+ with positive SISH),
* Neoadjuvant chemotherapy and intra-tumour clips indicated at the multidisciplinary consultation meeting (RCP).
* Signed Informed Consent Form

Exclusion Criteria:

* pregnant or breast-feeding women
* Have had a haematoma requiring level II analgesics at the time of the diagnostic biopsy.
* Known coagulation disorders
* Individual deprived of liberty or placed under the authority of a tutor, or a currator
* Not be affiliated to a social security regimen

Where it's running

• Centre de lutte contre le cancer Eugène Marquis
  Rennes, France Recruiting

Study contacts

• Principal investigator: Fanny LE DU, Dr — Centre de lutte contre le cancer Eugène Marquis
• Study coordinator: Valérie JOLAINE, Dr
• Email: v.jolaine@rennes.unicancer.fr
• Phone: (0)299253036

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.