Identifying patients for cone optogenetics vision restoration

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to prepare for the first-in-human clinical trial of cone optogenetics for vision restoration in patients with inherited retinal dystrophies. It focuses on identifying eligible patients by estimating the proportion of low vision patients who have dormant, non-functional cone cells that can potentially be resensitized. The study utilizes optical coherence tomography (OCT) to assess the retinal structure of participants. By conducting this multicenter ocular imaging study, researchers hope to gather critical data for future therapeutic interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria (patients):

* Diagnosis of generalized IRD
* Low vision as defined as visual acuity worse or equal to 0.05 (or 20/400) in the study eye
* Availability of macular optical coherence tomography (OCT)

Inclusion Criteria (controls):

* Normal ophthalmic findings
* Availability of macular optical coherence tomography (OCT)

Exclusion Criteria (all):

* Other eye diseases with a significant effect on vision or retinal structure
* Extraocular disease affecting retinal structure such as neurodegenerative diseases

Where it's running

• University of California San Francisco, Department of Ophthalmology
  San Francisco, California, United States Recruiting
• Bascom Palmer Eye Institute
  Miami, Florida, United States Recruiting
• University of Pittsburgh, Department of Ophthalmology
  Pittsburgh, Pennsylvania, United States Recruiting
• Beijing Institute of Ophthalmology
  Beijing, China Recruiting
• Universitätsklinikum Tübingen Augenklinik
  Tübingen, Germany Recruiting
• Semmelweis University, Department of Ophthalmology
  Budapest, Hungary Recruiting

Study contacts

• Principal investigator: Nicolas Feltgen, MD — University Hospital Basel/Institute of Molecular and Clinical Ophthalmology Basel, Switzerland
• Study coordinator: Lucas Janeschitz-Kriegl, MD
• Email: lucas.janeschitz@iob.ch
• Phone: +41787494373

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.