Identifying markers for endometrial receptivity during pregnancy
Official title: Transcriptome Profiling and Immune/ Biochemical Markers of Peripheral Blood to Predict Endometrial Receptivity and Successful Implantation
Run by Chinese University of Hong Kong · NCT03925311 · Data updated 2026-11-12
This study is trying to find out if certain biological markers can help predict the best time for a fertilized egg to implant in the uterus during pregnancy for women aged 20-40.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years to 40 Years |
| Sex | Women only |
| Enrollment | 220 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Status | Recruiting |
| Started | April 20, 2015 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | March 27, 2025 |
| Trial ID | NCT03925311 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women aged 20-40 who are trying to conceive and have no significant uterine anomalies.
✕Probably not a fit
Patients with uncorrected uterine anomalies, intrauterine adhesions, or adenomyosis may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify and correlate biochemical markers that reflect the window of implantation (WOI) during the midluteal phase of the menstrual cycle. Participants aged 20-40 will undergo endometrial biopsy and blood sampling at specific time points, including pre-conception and during pregnancy. The goal is to establish reliable clinical and biochemical indicators of WOI, which is crucial for successful implantation and pregnancy outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and identification of optimal conditions for implantation, potentially enhancing pregnancy rates.
How similar studies have gone: While there have been studies exploring endometrial receptivity, this specific approach of correlating biochemical markers with WOI is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Age 20-40 years. Exclusion Criteria: * Uncorrected uterine anomalies, such as septate or bicornuate uterus, fibroids (submucous/intramural). * Intrauterine adhesions. * Adenomyosis.
Where it's running
-
Chinese University of Hong Kong
Hong Kong, Hong Kong Recruiting
Study contacts
- Principal investigator: Pui Wah Jacqueline Chung, MBBS — Chinese University of Hong Kong
- Study coordinator: Hiu Tan Margaret Lee
- Email: margaretlee@cuhk.edu.hk
- Phone: 85235051764
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.