Identifying markers for endometrial receptivity during pregnancy
Transcriptome Profiling and Immune/ Biochemical Markers of Peripheral Blood to Predict Endometrial Receptivity and Successful Implantation
Chinese University of Hong Kong · NCT03925311
This study is trying to find out if certain biological markers can help predict the best time for a fertilized egg to implant in the uterus during pregnancy for women aged 20-40.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 220 (estimated) |
| Ages | 20 Years to 40 Years |
| Sex | Female |
| Sponsor | Chinese University of Hong Kong (other) |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT03925311 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify and correlate biochemical markers that reflect the window of implantation (WOI) during the midluteal phase of the menstrual cycle. Participants aged 20-40 will undergo endometrial biopsy and blood sampling at specific time points, including pre-conception and during pregnancy. The goal is to establish reliable clinical and biochemical indicators of WOI, which is crucial for successful implantation and pregnancy outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 20-40 who are trying to conceive and have no significant uterine anomalies.
Not a fit: Patients with uncorrected uterine anomalies, intrauterine adhesions, or adenomyosis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and identification of optimal conditions for implantation, potentially enhancing pregnancy rates.
How similar studies have performed: While there have been studies exploring endometrial receptivity, this specific approach of correlating biochemical markers with WOI is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Age 20-40 years. Exclusion Criteria: * Uncorrected uterine anomalies, such as septate or bicornuate uterus, fibroids (submucous/intramural). * Intrauterine adhesions. * Adenomyosis.
Where this trial is running
Hong Kong
- Chinese University of Hong Kong — Hong Kong, Hong Kong (RECRUITING)
Study contacts
- Principal investigator: Pui Wah Jacqueline Chung, MBBS — Chinese University of Hong Kong
- Study coordinator: Hiu Tan Margaret Lee
- Email: margaretlee@cuhk.edu.hk
- Phone: 85235051764
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Pregnancy Related, Transcriptome, endometrial receptivity