Identifying markers for curve progression in adolescent idiopathic scoliosis
Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis
This study is trying to find genetic markers that can help predict how scoliosis will progress in teenagers, so doctors can better decide who might need surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 380 (estimated) |
| Ages | 10 Years to 13 Years |
| Sex | Female |
| Sponsor | University of Colorado, Denver Academic / other |
| Locations | 1 site (Denver, Colorado) |
| Trial ID | NCT02315729 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify potential genetic markers that may predict the progression of spinal curves in adolescents with idiopathic scoliosis. The researchers hypothesize that specific alterations in these markers will correlate with curve progression over time. By understanding these molecular mechanisms, the study seeks to develop a non-invasive diagnostic test that could help in predicting which patients may require surgical intervention. The ultimate goal is to improve patient outcomes by enabling earlier and more targeted treatment for those at risk.
Who should consider this trial
Good fit: Ideal candidates are females aged 10-13 years diagnosed with mild to moderate idiopathic scoliosis.
Not a fit: Patients with scoliosis due to causes other than idiopathic, or those with a history of spine surgery or certain medical conditions, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better prediction of scoliosis progression and more timely interventions for affected adolescents.
How similar studies have performed: While the approach of identifying genetic markers in scoliosis is promising, it remains largely untested in this specific context, making this study relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Females aged 10-13 years * Diagnosed with mild-moderate spine deformity (Cobb angle 15-30 degrees) Exclusion Criteria: * Patients with scoliosis other than idiopathic * Trauma * Inflammatory disease * Malignancies * Diabetes * History of previous spine surgery
Where this trial is running
Denver, Colorado
- Children'S Hospital of Colorado — Denver, Colorado, United States (Recruiting)
Study contacts
- Principal investigator: Evalina L Burger, MD — University of Colorado, Denver
- Study coordinator: jiandong hao
- Email: jiandong.hao@cuanschutz.edu
- Phone: 303-724-7457
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.