Identifying markers for curve progression in adolescent idiopathic scoliosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify potential genetic markers that may predict the progression of spinal curves in adolescents with idiopathic scoliosis. The researchers hypothesize that specific alterations in these markers will correlate with curve progression over time. By understanding these molecular mechanisms, the study seeks to develop a non-invasive diagnostic test that could help in predicting which patients may require surgical intervention. The ultimate goal is to improve patient outcomes by enabling earlier and more targeted treatment for those at risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Females aged 10-13 years
* Diagnosed with mild-moderate spine deformity (Cobb angle 15-30 degrees)

Exclusion Criteria:

* Patients with scoliosis other than idiopathic
* Trauma
* Inflammatory disease
* Malignancies
* Diabetes
* History of previous spine surgery

Where it's running

• Children'S Hospital of Colorado
  Denver, Colorado, United States Recruiting

Study contacts

• Principal investigator: Evalina L Burger, MD — University of Colorado, Denver
• Study coordinator: jiandong hao
• Email: jiandong.hao@cuanschutz.edu
• Phone: 303-724-7457

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comfort Tote to help recovery after scoliosis surgery in teens

  This study tests whether a therapeutic Comfort Tote can reduce pain and anxiety after surgery for adolescent idiopathic scoliosis.

  Recruiting Columbia University · New York, New York · NCT07632833

• Erector spinae plane block to reduce post-operative pain after posterior spinal fusion in children

  This will try giving an erector spinae plane block with ropivacaine to see if it reduces pain and the need for opioid pain medicine after posterior spinal fusion in children with adolescent idiopathic or neuromuscular scoliosis.

  Recruiting Phase 3 University of California, San Francisco · San Francisco, California · NCT07561827

• MRI-guided dynamic support for correcting adolescent scoliosis

  This pilot tests whether an MRI-compatible air-padded support with programmable pneumatic control can quickly reduce spinal curvature in 10–16-year-olds with mild to moderate adolescent idiopathic scoliosis.

  Recruiting Chinese University of Hong Kong · Tsim Sha Tsui, Kowloon · NCT07246122

• Detecting scoliosis progression without X-rays using Momentum Spine app

  This study tests whether the Momentum Spine app can reliably detect scoliosis progression in 8-18 year olds without radiographs and guide follow-up care.

  Recruiting Children's Hospital Los Angeles · Los Angeles, California · NCT06825611

• Examining how spinal manipulation affects motor control in adolescents with scoliosis

  This study is testing how spinal manipulation affects movement control in teenagers with scoliosis to see if it helps them improve their balance and muscle function.

  Recruiting The First Affiliated Hospital of Zhejiang Chinese Medical University · Hangzhou · NCT06758115

• Using a 3D camera to assess scoliosis in adolescents

  This study is testing a new way to check the spine of teenagers with scoliosis using a special 3D camera to see if it’s better and safer than traditional X-rays.

  Recruiting The First Affiliated Hospital of Zhejiang Chinese Medical University · Hangzhou, Zhejiang · NCT06717568

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.