Identifying infections after major surgery using gene expression changes
Changes in Host Gene Expression to Differentiate Between Systemic Inflammation and Infection After Major Surgery
St. Antonius Hospital · NCT06116656
This study is testing if changes in certain genes in the blood can help doctors tell if adult patients who had major surgery have an infection or just a normal inflammatory response.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | St. Antonius Hospital (other) |
| Locations | 2 sites (Breda and 1 other locations) |
| Trial ID | NCT06116656 on ClinicalTrials.gov |
What this trial studies
This observational study aims to validate specific gene signatures that can differentiate between postoperative infections and non-infected systemic inflammatory response syndrome (SIRS) in adult patients undergoing major noncardiac surgery. By analyzing blood samples taken at various time points post-surgery, researchers hope to improve diagnostic accuracy and timely interventions. The study involves a multicenter approach, collecting blood samples to assess changes in host gene expression related to infection risk.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old undergoing major noncardiac surgery with a risk of infection greater than 20%.
Not a fit: Patients under 18 years old, those undergoing emergency surgery, or individuals unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and timely diagnoses of postoperative infections, potentially improving patient outcomes.
How similar studies have performed: Other studies have explored gene expression for diagnostic purposes, but this specific approach to differentiate between SIRS and infection post-surgery is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>18 years * Major noncardiac surgery with infection risk \>20% Exclusion Criteria: * Age \<18 years * Emergency surgery * Inability to provide informed consent.
Where this trial is running
Breda and 1 other locations
- Amphia hospital — Breda, Netherlands (RECRUITING)
- St Antonius hospital — Nieuwegein, Netherlands (RECRUITING)
Study contacts
- Study coordinator: Peter Noordzij
- Email: p.noordzij@antoniusziekenhuis.nl
- Phone: +31883203000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Infections, Sepsis