Identifying infection markers in invasive fusariosis
Official title: Multicenter Study on Invasive Fusariosis : Looking for Markers of Infection and Resistance
Run by Central Hospital, Nancy, France · NCT04937751 · Data updated 2026-11-12
This study is trying to find out how common different types of Fusarium fungi are in patients with suspected fungal infections and see if certain markers in their blood can help identify these infections better.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Central Hospital, Nancy, France Academic / other |
| Locations | 1 site (Vandœuvre-lès-Nancy) |
| Status | Recruiting |
| Started | July 19, 2023 |
| Main results expected | July 2028 |
| Study ends | July 2028 |
| Registry record updated | February 23, 2024 |
| Trial ID | NCT04937751 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with suspected invasive fungal infections who are undergoing blood cultures or skin biopsies, as well as those diagnosed with fungal keratitis.
✕Probably not a fit
Patients with superficial fusarium infections, such as onychomycosis, are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to analyze the proportions of different Fusarium species in positive fungal cultures from patients suspected of invasive fungal infections or fungal keratitis. It will also evaluate the levels of specific biomarkers, such as galactomannans and beta (1,3)-D-glucans, and assess the detection of circulating DNA in both case and control groups. The study seeks to enhance the understanding of Fusarium infections and their resistance to common antifungal treatments.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic methods and treatment strategies for patients suffering from invasive fusariosis.
How similar studies have gone: While there is limited data on similar studies specifically targeting Fusarium infections, the approach of identifying biomarkers in fungal infections has shown promise in other contexts.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Suspicion of invasive fungal infection involving the performance of a blood culture or a skin biopsy or diagnosis of keratitis involving the taking of a cornea sample * Fungal culture carried out on this sample * Person having been informed of the research and not having opposed the use of their data Exclusion Criteria: * Clinical diagnosis of superficial fusarium wilt (onychomycosis, etc.)
Where it's running
-
CHRU Nancy
Vandœuvre-lès-Nancy, France Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.