Identifying heart issues in Fabry disease using advanced MRI techniques
Fabry Cardiomyopathy: Identification of Early Myocardial Structural and Tissue Abnormalities Using Multiparametric MRI
NA · University Health Network, Toronto · NCT04856059
This study is testing if advanced MRI techniques can help find heart problems early in people with Fabry disease to improve their treatment and outcomes.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Health Network, Toronto (other) |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT04856059 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of cardiac MRI T1 and T2 mapping in detecting early heart abnormalities in patients with Fabry disease. Fabry disease is a genetic disorder that can lead to serious heart complications, and early detection is crucial for improving patient outcomes. By utilizing advanced imaging techniques, the study aims to identify patients at increased risk of adverse events before irreversible damage occurs. The findings could lead to personalized treatment approaches for those affected by this condition.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older diagnosed with Fabry disease.
Not a fit: Patients with a history of myocardial infarction or contraindications to MRI may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enable earlier diagnosis and treatment of heart issues in Fabry disease patients, potentially improving their quality of life and longevity.
How similar studies have performed: Other studies using advanced cardiac MRI techniques have shown promise in detecting early heart abnormalities, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Fabry disease; * Age ≥ 18 years. Exclusion Criteria: * History of myocardial infarction; * Contraindication to MRI.
Where this trial is running
Toronto, Ontario
- University Health Network — Toronto, Ontario, Canada (RECRUITING)
Study contacts
- Principal investigator: Kate Hanneman — University Health Network, Toronto
- Study coordinator: Kate Hanneman
- Email: kate.hanneman@uhn.ca
- Phone: 416-323-6400
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Fabry Disease, Fabry disease, Fabry cardiomyopathy, cardiac MRI, CMR, T1 mapping, T2mapping