Identifying heart issues in Fabry disease using advanced MRI techniques
Official title: Fabry Cardiomyopathy: Identification of Early Myocardial Structural and Tissue Abnormalities Using Multiparametric MRI
Run by University Health Network, Toronto · NCT04856059 · Data updated 2026-11-12
This study is testing if advanced MRI techniques can help find heart problems early in people with Fabry disease to improve their treatment and outcomes.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | University Health Network, Toronto Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Status | Recruiting |
| Started | June 15, 2021 |
| Main results expected | March 31, 2029 |
| Study ends | March 31, 2029 |
| Registry record updated | April 16, 2026 |
| Trial ID | NCT04856059 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older diagnosed with Fabry disease.
✕Probably not a fit
Patients with a history of myocardial infarction or contraindications to MRI may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of cardiac MRI T1 and T2 mapping in detecting early heart abnormalities in patients with Fabry disease. Fabry disease is a genetic disorder that can lead to serious heart complications, and early detection is crucial for improving patient outcomes. By utilizing advanced imaging techniques, the study aims to identify patients at increased risk of adverse events before irreversible damage occurs. The findings could lead to personalized treatment approaches for those affected by this condition.
Why it matters
Potential benefit: If successful, this study could enable earlier diagnosis and treatment of heart issues in Fabry disease patients, potentially improving their quality of life and longevity.
How similar studies have gone: Other studies using advanced cardiac MRI techniques have shown promise in detecting early heart abnormalities, suggesting this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Fabry disease; * Age ≥ 18 years. Exclusion Criteria: * History of myocardial infarction; * Contraindication to MRI.
Where it's running
-
University Health Network
Toronto, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Kate Hanneman — University Health Network, Toronto
- Study coordinator: Kate Hanneman
- Email: kate.hanneman@uhn.ca
- Phone: 416-323-6400
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Anderson-Fabry disease fitness improvement program
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Using advanced heart MRI to improve diagnosis and risk prediction for rare cardiomyopathies
This project tests whether advanced cardiac MRI techniques can help diagnose and predict future risk for people with rare heart muscle diseases like Danon, Fabry, cardiac amyloidosis, Noonan syndrome, and cardiac sarcoidosis.
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Quality of life for people 65+ with Fabry disease, treated or untreated
This project will see if starting or continuing Fabry disease treatment changes quality of life over two and five years in people aged 65 and older.
-
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.