Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Identifying heart issues in Fabry disease using advanced MRI techniques

Official title: Fabry Cardiomyopathy: Identification of Early Myocardial Structural and Tissue Abnormalities Using Multiparametric MRI

Run by University Health Network, Toronto · NCT04856059 · Data updated 2026-11-12

This study is testing if advanced MRI techniques can help find heart problems early in people with Fabry disease to improve their treatment and outcomes.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment300 (estimated)
SponsorUniversity Health Network, Toronto
Academic / other
Locations1 site (Toronto, Ontario)
StatusRecruiting
StartedJune 15, 2021
Main results expectedMarch 31, 2029
Study endsMarch 31, 2029
Registry record updatedApril 16, 2026
Trial IDNCT04856059 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older diagnosed with Fabry disease.

Probably not a fit

Patients with a history of myocardial infarction or contraindications to MRI may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of cardiac MRI T1 and T2 mapping in detecting early heart abnormalities in patients with Fabry disease. Fabry disease is a genetic disorder that can lead to serious heart complications, and early detection is crucial for improving patient outcomes. By utilizing advanced imaging techniques, the study aims to identify patients at increased risk of adverse events before irreversible damage occurs. The findings could lead to personalized treatment approaches for those affected by this condition.

Why it matters

Potential benefit: If successful, this study could enable earlier diagnosis and treatment of heart issues in Fabry disease patients, potentially improving their quality of life and longevity.

How similar studies have gone: Other studies using advanced cardiac MRI techniques have shown promise in detecting early heart abnormalities, suggesting this approach may be effective.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Fabry disease;
* Age ≥ 18 years.

Exclusion Criteria:

* History of myocardial infarction;
* Contraindication to MRI.

Where it's running

  • University Health Network
    Toronto, Ontario, Canada
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.