Identifying genetic risks for neonatal diseases
A Genome-Wide Association Study on Chinese Preterm Neonates and Identification of Functional Variants for Susceptibility to Necrotising Enterocolitis
Chinese University of Hong Kong · NCT04074824
This study is trying to find out if certain genes and bacteria in the gut can increase the risk of a serious gut condition called necrotizing enterocolitis in premature babies.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 310 (estimated) |
| Sex | All |
| Sponsor | Chinese University of Hong Kong (other) |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT04074824 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify genetic factors and microbiome influences that may predispose preterm neonates to necrotizing enterocolitis (NEC). By employing a genome-wide association study (GWAS) approach, researchers will analyze genetic data from affected infants to uncover potential risk markers. The study focuses on understanding the etiology and pathophysiology of NEC, a severe condition that can lead to significant morbidity and mortality in neonates. The findings could pave the way for better prediction and management of NEC in vulnerable populations.
Who should consider this trial
Good fit: Ideal candidates for this study are Chinese infants admitted to the neonatal unit who are at risk for neonatal diseases.
Not a fit: Patients who refuse consent for the study will not benefit from the findings.
Why it matters
Potential benefit: If successful, this study could lead to the identification of genetic markers that help predict which neonates are at high risk for developing NEC, potentially improving early intervention strategies.
How similar studies have performed: While there have been studies investigating genetic factors in neonatal diseases, this specific approach using GWAS for NEC is relatively novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Chinese infants admitted in the neonatal unit (NNU) Exclusion Criteria: Refuse consent for study
Where this trial is running
Hong Kong
- Prince of Wales Hospital — Hong Kong, Hong Kong (RECRUITING)
Study contacts
- Principal investigator: Kathy Chan, Ph. D. — CUHK
- Study coordinator: Kathy Chan, Ph. D.
- Email: kathyyychan@cuhk.edu.hk
- Phone: 852 3505 2858
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Neonatal Disease, Necrotizing Enterocolitis