Identifying genetic markers for cardiovascular diseases
Cardiovascular Diseases: Investigating the Risk Factors and Clinical Features Using Multi-omics Technologies
This study is trying to find genetic markers that could help us understand why some people develop atherosclerotic cardiovascular disease while others do not, by looking at blood samples from a large group of participants.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Center for Strategic Planning, of the Federal Medical and Biological Agency Academic / other |
| Locations | 2 sites (Moscow and 1 other locations) |
| Trial ID | NCT06253481 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify genetic determinants associated with atherosclerotic cardiovascular disease (ASCVD) by recruiting participants from the inpatient department of the National Medical Research Center of Cardiology. Participants will be divided into two groups: those diagnosed with ASCVD and a control group without significant atherosclerotic lesions. Blood and serum samples will be collected for biobanking, and a genome-wide association study will be conducted to explore genetic markers linked to various ASCVD types. The study will involve at least 10,000 participants and will run until December 2023.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who are hospitalized and can provide informed consent.
Not a fit: Patients with conditions such as HIV, syphilis, hepatitis B and C, or those whose ASCVD status cannot be confirmed may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the identification of genetic markers that help in the early detection and prevention of cardiovascular diseases.
How similar studies have performed: Other studies have shown success in identifying genetic markers for cardiovascular diseases, suggesting that this approach is promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: 1. At least 18 years of age; 2. Informed consent; 3. An in-patient available for a comprehensive assessment for ASCVD. Exclusion criteria: 1. Refusal to participate; 2. Positive/negative ASCVD impossible to confirm; 3. HIV, syphilis, hepatitis B and C; 4. Any other criteria deemed reasons for exclusion by the Principal Investigator
Where this trial is running
Moscow and 1 other locations
- National Medical Research Center of Cardiology named after Academician E.I. Chazov, Ministry of Health of the Russian Federation — Moscow, Russian Federation (Recruiting)
- Federal State Budgetary Institution Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency — Moscow, Russian Federation (Recruiting)
Study contacts
- Principal investigator: Marat V. Ezhov, M.D., Ph.D — National Medical Research Center of Cardiology named after Academician E.I. Chazov, Ministry of Health of the Russian Federation
- Study coordinator: Veronika V. Erema, M.D., Ph.D
- Email: VErema@cspfmba.ru
- Phone: +7 (495) 540-61-71
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.