Identifying genetic markers for Brugada Syndrome diagnosis
Unveiling the Genetic Landscape of Brugada Syndrome: Novel Biomarker Discovery for Precise Diagnosis
This study is testing if new genetic tools can help doctors better diagnose Brugada Syndrome and create more personalized treatment plans for patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 350 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS Policlinico S. Donato Academic / other |
| Locations | 1 site (San Donato Milanese, Milan) |
| Trial ID | NCT06647927 on ClinicalTrials.gov |
What this trial studies
This research focuses on improving the diagnosis of Brugada Syndrome (BrS) through advanced genetic sequencing techniques. By developing a genetic signature and identifying specific biomolecular profiles, the study aims to enhance understanding of the syndrome's molecular mechanisms. The approach includes a multi-omic strategy that integrates whole-exome sequencing and machine learning to uncover altered pathways related to BrS. The ultimate goal is to facilitate personalized treatment plans and refined risk assessment for patients affected by BrS.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who have been diagnosed with Brugada Syndrome.
Not a fit: Patients who do not have Brugada Syndrome or are under 18 years old will not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and efficient diagnoses of Brugada Syndrome, enabling better-targeted therapies.
How similar studies have performed: Other studies have shown promise in using genetic sequencing for diagnosing cardiac conditions, suggesting potential success for this approach in Brugada Syndrome.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * Patients affected by Brugada Syndrome * Patients who signs the Informed Consent Exclusion Criteria: * None
Where this trial is running
San Donato Milanese, Milan
- Irccs Policlinico San Donato — San Donato Milanese, Milan, Italy (Recruiting)
Study contacts
- Study coordinator: Giuseppe Ciconte MD, PhD
- Email: Giuseppe.Ciconte@grupposandonato.it
- Phone: +390252774260
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.