Identifying genetic factors related to knee injuries in athletes
Study on Susceptibility Genes of Anterior Cruciate Ligament, Patella Dislocation and Discoid Meniscus
This study is trying to find out if certain gene changes make athletes more likely to get knee injuries like ACL tears and meniscus damage.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Sex | All |
| Sponsor | Peking University Third Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT04997538 on ClinicalTrials.gov |
What this trial studies
This observational study aims to sequence the genomes of individuals with sports-related knee injuries to identify gene mutations associated with conditions like anterior cruciate ligament ruptures and meniscus injuries. By analyzing the exomes, researchers will explore the molecular mechanisms and signaling pathways that contribute to these injuries. The study seeks to uncover genetic risk factors and formulate scientific hypotheses regarding the role of specific gene mutations in sports injuries.
Who should consider this trial
Good fit: Ideal candidates include individuals with a history of joint sports injuries or those with a genetic predisposition to such injuries.
Not a fit: Patients whose joint injuries are caused by external trauma or who have concurrent injuries may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for knee injuries in athletes.
How similar studies have performed: While the specific approach of this study may be novel, similar studies have shown promise in identifying genetic factors related to sports injuries.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients with joint sports injuries. 2. Follow-up patients after sports injury. 3. Patients with genetic predisposition to sports injuries. 4. Patients with family genetic predisposition to exercise-related diseases and their relatives. Exclusion Criteria: 1. Patients with joint damage caused by external force. 2. The patient is accompanied by other injuries at the same time.
Where this trial is running
Beijing, Beijing
- Institute of Sports Medicine, Peking University Third Hospital — Beijing, Beijing, China (Recruiting)
Study contacts
- Study coordinator: Jia-Kuo Yu
- Email: yujiakuo@126.com
- Phone: 01082267392
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.