Identifying genetic factors linked to unexpected infant deaths

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter genetic study aims to identify new genetic variants associated with sudden infant death syndrome (SIDS) through whole-genome sequencing of family trios. The study will include cases of sudden unexpected death in infants (SUDI) both retrospectively from a national registry and prospectively at referral centers. Whole genome sequencing will be performed on identified SIDS cases and their biological parents to analyze potential pathogenic allelic variants. The research is part of a larger project exploring genetics, neurobiology, and radio-anatomy related to SUDI.

Why it matters

Who can join: the full rules

Child Inclusion Criteria

* Death of a child between 0 and 2 years of age due to sudden unexpected death in infant
* Child included in the French SUDI registry with effective participation in the biocollection
* Children who also meet the inclusion criteria for the BIOMINRISK-NEUROBIO (axis 2) and BIOMINRISK-RADIO-ANAT (axis 3) studies in the overall BIOMINRISK project.

Parents Inclusion Criteria

* Biological parents of the child included in the BIOMINRISK study
* Parents who have both signed the consent form for blood collection and inclusion of their samples in the biocollection
* parents beneficiaries of a social security or similar scheme

Child Exclusion Criteria:

* Presence of a known metabolic, genetic or syndromic pathology at the time of death

Parents Exclusion Crtiteria:

* Parent under guardianship
* Presence of a known metabolic, genetic or syndromic pathology

Where it's running

• Nantes University Hospital
  Nantes, Loire-Atlantique, France Recruiting
• CHU Amiens
  Amiens, France Recruiting
• CHU Angers
  Angers, France Recruiting
• CHU Besançon
  Besançon, France Recruiting
• APHP - Hôpital Jean Verdier
  Bondy, France Recruiting
• CHU Brest
  Brest, France Recruiting

Study contacts

• Principal investigator: Fleur Lorton — Nantes University Hospital
• Study coordinator: Fleur Lorton
• Email: Fleur.LORTON@chu-nantes.fr
• Phone: 33 2 40 08 38 06

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.