Identifying genetic factors in Parkinson's disease families
Parkinson's Families Project
This study is trying to find new genes that might cause Parkinson's disease in younger people and those with family members who have it, to help improve diagnosis and treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 16 Years and up |
| Sex | All |
| Sponsor | University College, London Academic / other |
| Locations | 2 sites (London and 1 other locations) |
| Trial ID | NCT02760108 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify new genes that predispose individuals to Parkinson's Disease and Parkinsonism by examining the genetic makeup of affected individuals and their family members. The focus is on two specific groups: those who developed Parkinson's before the age of 45 and those with a family history of the disease. By studying these familial connections, researchers hope to uncover genetic variations that contribute to the condition, which could lead to improved diagnosis and targeted treatments. The study seeks to enhance understanding of the disease's genetic underpinnings and potentially develop interventions that can be applied earlier in the disease process.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with Parkinson's disease or parkinsonism, particularly those with early onset or a family history of the condition.
Not a fit: Patients without a family history of Parkinson's or those diagnosed after the age of 45 may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more effective treatments for Parkinson's disease.
How similar studies have performed: Other studies have shown success in identifying genetic factors related to Parkinson's disease, making this approach promising yet still requiring further exploration.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Clinical diagnosis of Parkinson's disease or parkinsonism, and either family history of Parkinson's/parkinsonism (first or second degree family member affected by Parkinson's or parkinsonism) AND/OR Early onset Parkinson's/parkinsonism (symptom onset before the age of 45 years) First or second degree family member of an Index Case, affected or unaffected by Parkinson's/parkinsonism. Aged over 16 years Exclusion Criteria: Lack of capacity to consent to participate in the project.
Where this trial is running
London and 1 other locations
- Royal Free London NHS Foundation Trust — London, United Kingdom (Recruiting)
- University College London Hospitals NHS Foundation Trust — London, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Huw Morris, PhD, FRCP — University College, London
- Study coordinator: Study Coordinator
- Email: ion.pdresearch@ucl.ac.uk
- Phone: 02080168174
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.