Identifying genetic factors in Listeriosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the genetic susceptibility to Listeriosis, a severe foodborne infection primarily affecting the elderly and immunocompromised individuals. It is part of the ongoing MONALISA project, which has been collecting data since 2009 to analyze risk factors and outcomes associated with Listeriosis. The study aims to identify genetic markers that may explain why some individuals develop severe forms of the disease, including neurolisteriosis, while others do not. By analyzing human biological samples from affected patients and their relatives, the research seeks to enhance treatment and prevention strategies for this rare infection.

Why it matters

Who can join: the full rules

Inclusion Criteria for patients with Listeriosis :

* Microbiologically documented Listeriosis (either a severe form of listeriosis, or an atypical form of listeriosis, or less than 40 years old and without any co-morbidity identified)
* Affiliated or beneficiary of a social security system
* Informed and written consent

Inclusion Criteria for volunteers related to patients with Listeriosis (after identifying a genetic susceptibility in the patient with Listeriosis) :

* defined as father, mother, brother (s), sister (s), child (ren), grandparent (s), uncle (s), aunt (s), cousin (s), nephew (s), niece (s).
* Affiliated or beneficiary of a social security system
* Informed and written consent

Exclusion Criteria for volunteers related to patients with Listeriosis:

* Inability to consent

Where it's running

• Centre Médical de l'Institut Pasteur
  Paris, France Recruiting

Study contacts

• Study coordinator: Marc Lecuit
• Email: marc.lecuit@pasteur.fr
• Phone: +33 1 40 61 34 20

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.