Identifying genetic factors in familial papillary thyroid cancer
A Strategy to Search for Genes Predisposing to Papillary Carcinoma of the Thyroid When Mutated
Ohio State University Comprehensive Cancer Center · NCT02776969
This study is trying to find out if certain genes are linked to familial papillary thyroid cancer by looking at family histories and samples from affected individuals and their relatives.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Ohio State University Comprehensive Cancer Center (other) |
| Locations | 1 site (Columbus, Ohio) |
| Trial ID | NCT02776969 on ClinicalTrials.gov |
What this trial studies
This project aims to uncover genetic risk factors linked to familial papillary thyroid carcinoma (PTC), a cancer known for its high heritability. The study employs various methodologies, including loss of heterozygosity studies and comparative gene expression analysis, to identify potential genetic causes. Participants will provide family and medical histories, as well as blood or saliva samples for genetic analysis. The study also seeks to involve family members of affected individuals to enhance the understanding of genetic links.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with PTC who have a family history of the disease in three or more living relatives.
Not a fit: Patients with known germline predispositions or those who do not speak English may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved genetic screening and risk assessment for familial papillary thyroid cancer.
How similar studies have performed: Other studies have successfully identified genetic factors in familial cancers, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with a diagnosis of PTC and a family history of PTC in 3 or more living relatives * Affected and unaffected family members of the proband\* * For familial cases (families with 4 or more cases of PTC), participation will be offered to all living family members with PTC or benign thyroid disease as well as selected unaffected first and second degree relatives. Participation may also be offered to spouses when needed for analyzing parent/offspring samples. Exclusion Criteria: * Known germline predisposition (ex: pathogenic PTEN variant) * Non-English speaking
Where this trial is running
Columbus, Ohio
- Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States (RECRUITING)
Study contacts
- Principal investigator: Matthew Ringel, MD — Ohio State University Comprehensive Cancer Center
- Study coordinator: Ohio State University Comprehensive Cancer Center
- Email: OSUCCCClinicaltrials@osumc.edu
- Phone: 614-293-5066
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Thyroid, Papillary Carcinoma, Gene Hunting, Familial