Identifying genetic factors in early-onset COPD
Genetic Epidemiology of Severe, Early-Onset Chronic Obstructive Pulmonary Disease
This study is trying to find out if certain genes make younger people with severe COPD more likely to develop the condition, even if they don't smoke.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Sex | All |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT01177618 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on individuals with severe chronic obstructive pulmonary disease (COPD) who are 52 years old or younger. The aim is to identify genetic factors that may predispose certain individuals to develop COPD, despite the common risk factor of cigarette smoking. Participants will undergo a respiratory questionnaire, breathing tests, and blood draws, which can be conducted at home or through remote data collection. The findings could lead to new treatment methods for those affected by COPD.
Who should consider this trial
Good fit: Ideal candidates are individuals diagnosed with severe COPD at an early age (52 years or younger) with specific spirometry results.
Not a fit: Patients with severe alpha-1 antitrypsin deficiency or other chronic lung diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment options for individuals at risk of developing COPD.
How similar studies have performed: Previous studies have shown success in identifying genetic factors related to COPD, making this approach promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria for Early-Onset COPD Probands: * Early onset of COPD in individuals younger than 53 years old * Spirometry results that are indicative of severe COPD (FEV1 \< 40% predicted) * Physician-diagnosed COPD Exclusion Criteria for Early-Onset COPD Probands: * Severe alpha-1 antitrypsin deficiency * Other chronic lung diseases in participants with COPD (except asthma) * Pregnant * Any previous lung surgery including lung transplant or lung reduction volume surgery (LVRS); unless prior Pulmonary Function Tests are available
Where this trial is running
Boston, Massachusetts
- Brigham and Women's Hospital — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Edwin K. Silverman, M.D., Ph.D. — Brigham and Women's Hospital
- Study coordinator: Edwin K. Silverman, M.D., Ph.D.
- Email: ed.silverman@channing.harvard.edu
- Phone: 617-525-2128
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.