Identifying genetic factors in drug reactions in children and adults
Canadian Pharmacogenomics Network for Drug Safety
This study is trying to find out if genetic differences in children and adults can help explain why some people have bad reactions to medications while others do not.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 7000 (estimated) |
| Sex | All |
| Sponsor | University of British Columbia Academic / other |
| Locations | 1 site (Vancouver, British Columbia) |
| Trial ID | NCT00414115 on ClinicalTrials.gov |
What this trial studies
This observational study aims to collect DNA and plasma samples from children and adults who experience adverse drug reactions (ADRs) and those who do not. By comparing these samples, the study seeks to identify genetic differences that may contribute to ADRs and develop personalized drug dosing guidelines. The research will also analyze the use of medical services and vital statistics between participants with and without ADRs. The study will utilize a hospital-based active surveillance network across major hospitals in Canada to gather clinical material.
Who should consider this trial
Good fit: Ideal candidates include children under 19 who have taken drugs and their biological parents, as well as adults for validation purposes.
Not a fit: Patients who do not speak or understand English (except in Quebec) may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to personalized drug dosing guidelines that minimize the risk of adverse drug reactions in patients.
How similar studies have performed: Other studies have shown success in identifying genetic factors related to drug reactions, making this approach promising yet still novel in its specific application to children.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children under 19 years who have taken drugs. * Biological parents of children who have had an ADR. * Patients/parents who speak and understand English (except in Quebec). * Adults (for validation of findings in children)
Where this trial is running
Vancouver, British Columbia
- Children's and Women's Health Centre of British Columbia — Vancouver, British Columbia, Canada (Recruiting)
Study contacts
- Principal investigator: Bruce Carleton, Pharm. D. — University of British Columbia
- Study coordinator: Bruce Carleton, PharmD.
- Email: bcarleton@popi.ubc.ca
- Phone: 604-875-2179
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.