Identifying genetic factors affecting COVID-19 severity
Identification of the Genetic Bases Determining COVID-19 Clinical Variability in the Italian Population
This study is trying to find out if certain genetic traits make COVID-19 worse for some people compared to others by looking at the genes of at least 2,000 patients in Italy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Siena Academic / other |
| Locations | 1 site (Siena) |
| Trial ID | NCT04549831 on ClinicalTrials.gov |
What this trial studies
The GEN-COVID multicenter study aims to uncover the genetic variants in the host genome that contribute to the clinical variability observed in COVID-19 patients. By conducting genetic investigations such as whole exome sequencing and genome-wide association studies, the study seeks to correlate genetic factors with disease severity and long-term outcomes. Clinical data will also be collected to provide a comprehensive understanding of the disease's impact on different individuals. The study plans to enroll at least 2,000 patients across multiple hospitals in Italy.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have tested positive for SARS-CoV-2.
Not a fit: Patients who are under 18 years old or have not tested positive for SARS-CoV-2 will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to personalized treatment strategies for COVID-19 based on genetic susceptibility.
How similar studies have performed: Other studies have shown promise in identifying genetic factors related to disease severity in various conditions, suggesting potential success for this approach in COVID-19.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> or equal to 18 * SARS-CoV-2 PCR positive on swab Exclusion Criteria: * none
Where this trial is running
Siena
- University of Siena — Siena, Italy (Recruiting)
Study contacts
- Principal investigator: Francesca Mari, MD, PhD — University of Siena
- Study coordinator: Alessandra Renieri, MD, PhD
- Email: alessandra.renieri@unisi.it
- Phone: 00390577233303
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.