Identifying genetic causes of inflammatory skin diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to uncover rare, disease-causing mutations associated with neutrophil-mediated inflammatory dermatoses (NMID). Utilizing next-generation sequencing, particularly whole exome sequencing, the study will explore genetic variants linked to these conditions. Additionally, it will assess the expression levels of known inflammatory proteins in skin samples to further understand the disease mechanisms. The research will involve collecting biological material and health-related data from participants diagnosed with NMID or serving as controls.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* written consent of the participating person
* diagnosis of a disease in the NMID form group or proband of the control group

Exclusion Criteria for patients:

* Missing informed consent if samples collected after 2014
* no diagnosis of NMID

Exclusion Criteria for healthy controls:

* Missing informed consent

Where it's running

• University Hospital Basel, Clinic of Dermatology
  Basel, Switzerland Recruiting

Study contacts

• Principal investigator: Alexander Navarini, Prof. Dr. med. — University Hospital Basel, Clinic of Dermatology
• Study coordinator: Alexander Navarini, Prof. Dr. med.
• Email: alexander.navarini@usb.ch
• Phone: +41 61 265 40 84

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.