Identifying genes linked to familial pituitary adenomas
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA
This study is trying to find out if certain genes are linked to pituitary tumors in families, especially for people with conditions like acromegaly and gigantism.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10000 (estimated) |
| Ages | 6 Years and up |
| Sex | All |
| Sponsor | Barts & The London NHS Trust Academic / other |
| Locations | 3 sites (Leicester and 2 other locations) |
| Trial ID | NCT00461188 on ClinicalTrials.gov |
What this trial studies
This research aims to discover new predisposition genes associated with endocrine tumors, particularly focusing on pituitary adenomas such as acromegaly and gigantism. Patients will be recruited from various Endocrine outpatient clinics and inpatient wards, with an emphasis on those showing evidence of hereditary conditions. The study will investigate the role of the AIP gene and its interactions in the development of familial and sporadic pituitary tumors. By understanding these genetic factors, the research seeks to shed light on the mechanisms behind pituitary tumorigenesis.
Who should consider this trial
Good fit: Ideal candidates include individuals with familial acromegaly, early onset acromegaly, or sporadic pituitary tumors.
Not a fit: Patients who do not consent to participate will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and management of pituitary tumors, potentially improving patient outcomes.
How similar studies have performed: Other studies have shown success in identifying genetic factors related to pituitary tumors, making this approach promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Familial acromegaly or other type of pituitary tumour OR * Early onset acromegaly or * Sporadic pituitary tumour Exclusion Criteria: * Do not consent
Where this trial is running
Leicester and 2 other locations
- Leicester Infirmary — Leicester, United Kingdom (Recruiting)
- Barts and the London medical School — London, United Kingdom (Recruiting)
- Royal Victoria Infirmary — Newcastle upon Tyne, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Marta Korbonits, MD PhD — Barts and the London Medical School
- Study coordinator: Marta Korbonits, MD PhD
- Email: m.korbonits@qmul.ac.uk
- Phone: 020 7882 6238
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.