Identifying genes linked to Alzheimer's Disease
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)
This study is trying to find out which genes might be linked to Alzheimer's Disease by collecting samples from families who have multiple members diagnosed with it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Indiana University Academic / other |
| Locations | 1 site (Nationwide, Indiana) |
| Trial ID | NCT00064870 on ClinicalTrials.gov |
What this trial studies
The Alzheimer's Disease Genetics Study aims to identify the genetic factors that contribute to Alzheimer's Disease by collecting biological samples from families with multiple members diagnosed with Alzheimer's or dementia. Eligible families must have at least two living blood-related individuals diagnosed with these conditions. The study will gather genetic material, which will be made available to qualified researchers under strict privacy agreements. This observational study spans multiple locations across the United States, facilitating participation from diverse families.
Who should consider this trial
Good fit: Ideal candidates for this study are families with at least two living members diagnosed with Alzheimer's Disease or other forms of dementia.
Not a fit: Patients who do not have a family history of Alzheimer's Disease or dementia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to a better understanding of the genetic causes of Alzheimer's Disease, potentially informing future prevention and treatment strategies.
How similar studies have performed: Other studies investigating genetic factors in Alzheimer's Disease have shown promise, suggesting that this approach could yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Two living family members diagnosed with AD or other dementia with any age of onset * Biological samples available * Fresh blood, or * Immortalized lymphoblastic cell lines, or * 3-5 grams of frozen cerebral cortex; fixed samples are not accepted Please note: this study does not include genetic counseling; because no personal identifying information such as name or date of birth is attached to samples, results of individual tests are not available to participants or family members. Exclusion Criteria: * Does not meet inclusion criteria * Member of a family that was included in the National Institute of Mental Health AD Genetics Sib Pair collection
Where this trial is running
Nationwide, Indiana
- Participants are being recruited from all over the United States — Nationwide, Indiana, United States (Recruiting)
Study contacts
- Principal investigator: Tatiana M. Foroud, PhD — National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indiana University
- Study coordinator: Study Coordinator
- Email: alzstudy@iu.edu
- Phone: 1-800-526-2839
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.