Identifying factors that help with weight loss and maintenance
Identification of Phenotypic Factors That Predict Success for Weight Loss and Long-term Weight Maintenance
This study is trying to find out what personalized weight loss strategies work best for overweight and obese people to help them lose weight and keep it off.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3200 (estimated) |
| Ages | 15 Years to 75 Years |
| Sex | All |
| Sponsor | University of Michigan Academic / other |
| Locations | 1 site (Ann Arbor, Michigan) |
| Trial ID | NCT02043457 on ClinicalTrials.gov |
What this trial studies
The Weight Management Program at the University of Michigan aims to discover effective strategies for long-term weight management in overweight and obese individuals. This observational study explores the idea that a personalized approach is necessary for treating obesity, rather than a one-size-fits-all method. Participants can choose between standard clinical care or various clinical studies focusing on nutrition, biological factors related to weight, and both approved and experimental treatments. The program emphasizes phenotyping to better understand individual responses to weight management strategies.
Who should consider this trial
Good fit: Ideal candidates include obese individuals aged over 20 with a BMI of 27 kg/m2 or higher, as well as lean individuals with a BMI between 17 and 27 kg/m2.
Not a fit: Patients with certain medical conditions, such as uncontrolled thyroid disease or unstable neuropsychiatric disorders, may not benefit from this study.
Why it matters
Potential benefit: If successful, this program could lead to more effective and personalized weight management strategies for patients struggling with obesity.
How similar studies have performed: Other studies have shown promise in personalized approaches to obesity treatment, suggesting that this method could be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Obese males and females: age \>20 years; Obese population defined as BMI \> or = 27 kg/m2 * Lean population BMI \< 27 but \> 17 kg/m2 * Able and willing to provide written informed consent for the trial Exclusion Criteria: * Evidence of inherited disorders of lipid metabolism. * History of Cancer within the last 5 years * Human immunodeficiency virus (HIV) antibody positive. * Patients with solid organ transplants. * Participation in any other clinical trial within 90 days of entry into this trial. * Pregnant or lactating females. * Uncontrolled thyroid disease * Unstable angina or NY heart association class II failure or above * Gastrointestinal disease specifically GI motility disorders * Unstable neuropsychiatric disease including major depression/anxiety, eating disorder such as binge eating, bulimia or anorexia * End stage renal or hepatic disease * Autoimmune disorders (e.g. SLE) * Body weight fluctuation of more than 5 kg in the previous 3 months * Prior bariatric surgery * A history or current alcohol/substance abuse and change in smoking habits or cessation in the past 6 months. * Women of childbearing age must use a reliable form of contraception. * Any medical condition, which in the opinion of the investigator would make the patient unsuitable for recruitment, or could interfere with the patient participating in or completing the protocol. * Unwilling or unable to consent for the study.
Where this trial is running
Ann Arbor, Michigan
- University of Michigan — Ann Arbor, Michigan, United States (Recruiting)
Study contacts
- Study coordinator: Amy E Rothberg, MD, PhD
- Email: arothber@med.umich.edu
- Phone: 734-647-5871
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.