Identifying factors related to low eosinophil counts in severe COPD exacerbations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify factors associated with low eosinophil counts in patients experiencing severe exacerbations of chronic obstructive pulmonary disease (COPD). It will assess demographic, physiological, and clinical characteristics that correlate with eosinopenia upon hospital admission. Additionally, the study will evaluate the time it takes for blood eosinophil counts to return to baseline levels after recovery from a severe exacerbation. The findings could help refine treatment decisions regarding inhaled corticosteroids in COPD management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Admitted to hospital with primary clinical diagnosis of exacerbation of COPD\*
* Smoking history of at least 10 pack years
* Airflow obstruction: FEV1/FVC ratio \< 0.7 confirmed on historic or inpatient spirometry
* Capacity to give informed consent to participate

Exclusion Criteria:

* Parasitic infection, systemic fungal infection (excluding infection limited to nails or skin), eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome or other conditions associated with a high eosinophil count#
* Active malignancy
* Maintenance oral prednisolone or other systemic steroids, anti-interleukin 5 therapy or other medication known to influence eosinophils
* Patients with poor venous access
* Investigator confirmed history of asthma
* Non-COPD related health problems which in the view of the primary investigator may compromise the conduct and completion of the study

ADDITIONAL CRITERIA FOR THE TIME TO RECOVERY FROM EOSINOPENIA ANALYSIS ONLY

Inclusion criteria:

* Eosinopenia on admission
* Uneventful recovery\*

  * Eosinopenia on admission who do not receive a further course of systemic corticosteroids or require emergency hospital admission for an acute illness in the six weeks following admission to hospital with a severe exacerbation of COPD.

Where it's running

• Northumbria Healthcare NHS Foundation Trust
  North Shields, United Kingdom Recruiting

Study contacts

• Principal investigator: Peter Ireland, MBBS — Northumbria Healthcare NHS Foundation Trust
• Study coordinator: Stephen Bourke, MBChB, PhD
• Email: stephen.bourke@nhct.nhs.uk
• Phone: 0191 293 4351

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.