Identifying factors influencing alcohol relapse in liver transplant patients
Risk and Protective Factors for Relapse to Alcohol Use in Patients With Alcohol-related Liver Disease and Undergoing Orthotopic Liver Transplantation
This study looks at what causes some liver transplant patients, who struggled with alcohol problems before, to relapse into drinking again after their surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 320 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna Academic / other |
| Locations | 1 site (Bologna) |
| Trial ID | NCT06749990 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify risk and protective factors for alcohol relapse in patients with alcohol-related liver disease who have undergone liver transplantation. It consists of both retrospective and prospective components, collecting clinical data from patient medical records and conducting assessments during routine follow-up visits. The study will analyze patients' medical history, laboratory results, and psychosocial backgrounds to better understand the factors influencing relapse after transplantation.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with alcohol-related liver disease who are undergoing liver transplantation.
Not a fit: Patients with major psychopathologies or active psychoses may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for preventing alcohol relapse in liver transplant patients, enhancing their long-term recovery and health outcomes.
How similar studies have performed: While similar studies have explored relapse factors in liver transplant patients, this specific observational approach focusing on both retrospective and prospective data collection is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who have signed the informed consent * Candidates for liver transplantation due to liver disease with alcohol-related etiology (either mono- or multifactorial) * For the retrospective part: patients who underwent OLT for ARLD during the time frame 2017-2022 Exclusion Criteria: * Major psychopathologies and active psychoses
Where this trial is running
Bologna
- IRCCS Azienda Ospedaliero-Universitaria di Bologna — Bologna, Italy (Recruiting)
Study contacts
- Principal investigator: Maria Cristina Morelli, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Study coordinator: Maria Cristina Morelli, MD
- Email: mariacristina.morelli@aosp.bo.it
- Phone: 0512144248
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.