Identifying factors for successful weight loss in people with obesity
Whole Body and Gut Microbiome Metabolic Flexibility to Predict Lifestyle Intervention Outcomes
This study is trying to find out how certain body factors can help people with obesity lose weight more effectively through exercise and diet changes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 25 Years to 45 Years |
| Sex | Female |
| Sponsor | Charles University, Czech Republic Academic / other |
| Locations | 3 sites (Prague and 2 other locations) |
| Trial ID | NCT06329349 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to explore how metabolic flexibility and gut microbiome characteristics can predict the outcomes of lifestyle interventions, specifically exercise and diet, in individuals with obesity. By conducting detailed physiological assessments, the study seeks to identify specific features that correlate with successful weight loss. Participants will undergo a series of interventions, including exercise and combined exercise with dietary changes, while their metabolic responses will be closely monitored. The goal is to personalize weight loss strategies based on individual metabolic profiles to enhance effectiveness.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 25-45 with a body mass index (BMI) greater than 30.
Not a fit: Patients with active cancer, diabetes, uncontrolled endocrine diseases, or those on specific therapies like corticosteroids or immune-suppressants may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective, personalized weight loss interventions for individuals living with obesity.
How similar studies have performed: While the concept of metabolic flexibility has been explored, this specific approach to predicting weight loss outcomes through metabolic and microbiome profiling is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI\>30 * age 25-45 years Exclusion Criteria: * active cancer * diabetes (medical history, fasting glycemia \>7.6 and/or 2hOGTT glycemia \>11.1) * uncontrolled endocrine diseases * corticosteroid therapy * immune-suppressive therapy * pregnancy * breastfeeding
Where this trial is running
Prague and 2 other locations
- University Hospital Kralovske Vinohrady — Prague, Czechia (Recruiting)
- Third Medical Faculty,Charles University — Prague, Czechia (Recruiting)
- Faculty of Sports Science — Prague, Czechia (Recruiting)
Study contacts
- Principal investigator: Jan Gojda — Charles University, Czech Republic
- Study coordinator: Jan Gojda, PhD
- Email: jan.gojda@lf3.cuni.cz
- Phone: +420267163031
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.