Identifying early symptoms of hand osteoarthritis
A Prospective Cohort Study of Patients Suffering From Hand Osteoarthritis
This study is trying to find early signs of hand osteoarthritis in people under 60 using advanced imaging to help identify those at risk for worsening symptoms.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | University Hospital, Montpellier Academic / other |
| Locations | 1 site (Montpellier) |
| Trial ID | NCT03650673 on ClinicalTrials.gov |
What this trial studies
This study aims to identify early onset symptoms in patients suffering from hand osteoarthritis using advanced imaging techniques such as ultrasound and MRI. By focusing on patients under 60 years old with specific clinical and radiological criteria, the study seeks to identify subgroups at high risk for disease progression. The primary endpoint is to specify patients who show signs of radiological progression through X-ray assessments. This prospective cohort approach will help in understanding the early stages of hand osteoarthritis.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals under 60 years old who exhibit early symptoms of hand osteoarthritis as defined by specific clinical and radiological criteria.
Not a fit: Patients with rheumatoid arthritis, inflammatory rheumatism, or advanced stages of osteoarthritis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier diagnosis and targeted interventions for patients with hand osteoarthritis, potentially improving their quality of life.
How similar studies have performed: While there have been studies focusing on osteoarthritis, this specific approach using imaging techniques for early identification of hand osteoarthritis symptoms is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Early digital osteoarthritis must combine the clinical AND radiological definition. Clinical definition: At least one of the following 4 criteria: Pain or stiffness or swelling or deformity of a digital joint (IPP and / or IPD) A breach of at least one PPI and / or IPD Age under 60 at the time of the first symptoms Clinical symptoms have been changing for less than 3 years Radiographic definition: The presence of the achievement of at least one PPI and / or IPD. Presence of at least two of the following three criteria: pinching, marginal subchondral condensation, marginal osteophyte Erosion on radiography is not an exclusion criteria \- Consent form signed Exclusion criteria: * patients suffering from rheumatoid arthritis, rheumatoid psoriasis or any other inflammatory rheumatism * patients suffering from metabolic diseasis such as gout, hemochromatosis, Wilson's disease; or from congenital disease such as displasie, osteogenesis, * Presence of advanced radiographic osteoarthritis based in Kellgreen Lawrence score (=4) in one joint among the 10 previous sites. * Not able to provide a sample of blood for any reasons * MRI contraindication * Being in exclusion period determined by another previous study * Subject non affiliated to social insurance * Pregnant or lactating women * Vulnerable people based in L1121-5 article of CSP * Elderly subject or protected subjects disabled to give their consent * Subjects private of freedom by court or administrative order
Where this trial is running
Montpellier
- Department of Rheumatology, CHU Montpellier — Montpellier, France (Recruiting)
Study contacts
- Principal investigator: Yves-Marie PERS, MD — University Hospital, Montpellier
- Study coordinator: Yves-Marie PERS, MD
- Email: ympers2000@yahoo.fr
- Phone: +33 618993804
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.