Identifying early symptoms of hand osteoarthritis
Official title: A Prospective Cohort Study of Patients Suffering From Hand Osteoarthritis
Run by University Hospital, Montpellier · NCT03650673 · Data updated 2026-11-12
This study is trying to find early signs of hand osteoarthritis in people under 60 using advanced imaging to help identify those at risk for worsening symptoms.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | University Hospital, Montpellier Academic / other |
| Locations | 1 site (Montpellier) |
| Status | Recruiting |
| Started | July 15, 2019 |
| Main results expected | July 31, 2028 |
| Study ends | October 31, 2028 |
| Registry record updated | September 30, 2025 |
| Trial ID | NCT03650673 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals under 60 years old who exhibit early symptoms of hand osteoarthritis as defined by specific clinical and radiological criteria.
✕Probably not a fit
Patients with rheumatoid arthritis, inflammatory rheumatism, or advanced stages of osteoarthritis may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to identify early onset symptoms in patients suffering from hand osteoarthritis using advanced imaging techniques such as ultrasound and MRI. By focusing on patients under 60 years old with specific clinical and radiological criteria, the study seeks to identify subgroups at high risk for disease progression. The primary endpoint is to specify patients who show signs of radiological progression through X-ray assessments. This prospective cohort approach will help in understanding the early stages of hand osteoarthritis.
Why it matters
Potential benefit: If successful, this study could lead to earlier diagnosis and targeted interventions for patients with hand osteoarthritis, potentially improving their quality of life.
How similar studies have gone: While there have been studies focusing on osteoarthritis, this specific approach using imaging techniques for early identification of hand osteoarthritis symptoms is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Early digital osteoarthritis must combine the clinical AND radiological definition. Clinical definition: At least one of the following 4 criteria: Pain or stiffness or swelling or deformity of a digital joint (IPP and / or IPD) A breach of at least one PPI and / or IPD Age under 60 at the time of the first symptoms Clinical symptoms have been changing for less than 3 years Radiographic definition: The presence of the achievement of at least one PPI and / or IPD. Presence of at least two of the following three criteria: pinching, marginal subchondral condensation, marginal osteophyte Erosion on radiography is not an exclusion criteria \- Consent form signed Exclusion criteria: * patients suffering from rheumatoid arthritis, rheumatoid psoriasis or any other inflammatory rheumatism * patients suffering from metabolic diseasis such as gout, hemochromatosis, Wilson's disease; or from congenital disease such as displasie, osteogenesis, * Presence of advanced radiographic osteoarthritis based in Kellgreen Lawrence score (=4) in one joint among the 10 previous sites. * Not able to provide a sample of blood for any reasons * MRI contraindication * Being in exclusion period determined by another previous study * Subject non affiliated to social insurance * Pregnant or lactating women * Vulnerable people based in L1121-5 article of CSP * Elderly subject or protected subjects disabled to give their consent * Subjects private of freedom by court or administrative order
Where it's running
-
Department of Rheumatology, CHU Montpellier
Montpellier, France Recruiting
Study contacts
- Principal investigator: Yves-Marie PERS, MD — University Hospital, Montpellier
- Study coordinator: Yves-Marie PERS, MD
- Email: ympers2000@yahoo.fr
- Phone: +33 618993804
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Intramuscular methylprednisolone for relieving hand osteoarthritis pain
This trial will test whether one or two doses of intramuscular methylprednisolone (120 mg or 40 mg) reduce hand pain more than a placebo in people with hand osteoarthritis.
-
Multiprofen-CC cream to reduce hand osteoarthritis pain
This trial will try Multiprofen-CC cream to see if applying it to the hands reduces pain in adults with hand osteoarthritis compared with a placebo.
-
Program for managing hand osteoarthritis
This study is testing a new program to help people with hand osteoarthritis improve their daily activities and see if it works well in real life.
-
Using metformin to treat hand osteoarthritis symptoms
This study is testing if metformin can help people with hand osteoarthritis feel less pain and improve their symptoms over 16 weeks.
-
Evaluating acupuncture for hand osteoarthritis
This study is testing whether acupuncture can help people with hand osteoarthritis feel less pain and improve their joint function.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.