Identifying early MRI markers for lung issues in extremely preterm infants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify early-life MRI biomarkers that can predict longer-term respiratory morbidity in infants born extremely preterm, specifically those under 29 weeks gestation. By utilizing advanced MRI techniques, the study will assess lung tissue and blood vessel development to better understand the risk of bronchopulmonary dysplasia (BPD). A total of 319 infants will be recruited from four centers, and their lung function will be monitored to improve early diagnosis and treatment strategies. The findings could enhance family counseling and the introduction of new therapies for BPD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Infants born at \<29 weeks gestation;
2. currently \<36 weeks PMA.

Exclusion Criteria:

1. Known interstitial lung disease, congenital lung anomaly, ciliary dysfunction, immunodeficiency, cystic fibrosis, neuromuscular disease, or structural heart disease (other than atrial septal defect/hemodynamically insignificant ventricular septal defect/patent ductus arteriosus);
2. genetic syndrome or congenital anomaly;
3. contraindications for MRI or transport;
4. invasive or non-invasive ventilation that cannot be safely removed for MRI;
5. current respiratory infection;
6. family cannot speak English/French;
7. transferred to another hospital prior to baseline study visit
8. not receiving follow-up at one of the study centres.

Where it's running

• The Children's Hospital of Eastern Ontario
  Ottawa, Ontario, Canada Recruiting
• Mount Sinai Hospital
  Toronto, Ontario, Canada Recruiting
• Montreal Children's Hospital
  Montreal, Quebec, Canada Recruiting
• CHU-Sainte Justine
  Montreal, Quebec, Canada Active not recruiting

Study contacts

• Principal investigator: Sherri Katz — Children's Hospital of Eastern Ontario
• Study coordinator: Sherri Katz
• Email: skatz@cheo.on.ca
• Phone: (613) 737-7600

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Evaluating L-Citrulline for Preterm Infants with Lung and Gut Issues

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.