Identifying causes of organ failure in critically ill patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to identify the underlying mechanisms of organ failure in critically ill patients admitted to the ICU by measuring biomarkers associated with ferroptosis, a type of iron-related cell death. By analyzing blood and biological fluid samples, researchers hope to determine if ferroptosis contributes to organ failure in patients suffering from conditions such as sepsis, trauma, or subarachnoid hemorrhage. The findings could pave the way for new therapeutic strategies targeting this biochemical pathway in the future.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Admitted to the ICU of UZA
* Critically ill and predicted to be hospitalised in the ICU for \> 48 hours (i.e. mostly patients admitted for sepsis, trauma, haemorrhagic shock, neurological catastrophe … which means at risk to develop mono-or multiple organ failure)
* With arterial line in place (for blood sampling)

Exclusion Criteria:

* Refusal of consent by patient or closest relative
* Postoperative patients after major surgery in whom prolonged ICU stay is not foreseen (i.e. elective cardiac surgery

Where it's running

• University Hospital Antwerp
  Edegem, Belgium Recruiting

Study contacts

• Principal investigator: Philippe Jorens, MD, PhD — University Hospital, Antwerp
• Study coordinator: Tom Stroobants, MD
• Email: tom.stroobants@uza.be
• Phone: +32 3 821 / 24 52

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.