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Identifying cardiovascular risk in heart failure patients using exercise test data

Metabolic Exercise Test Data Combined with Cardiac and Kidney Indexes (MECKI) Score Evolution: Study of Cardiovascular Risk in Patients with Heart Failure

Centro Cardiologico Monzino · NCT06884631

This study is trying to see if using exercise test data can help identify heart failure patients at higher risk for cardiovascular problems.

Quick facts

Study typeObservational
Enrollment10000 (estimated)
Ages18 Years and up
SexAll
SponsorCentro Cardiologico Monzino (other)
Locations26 sites (Milan, Italy and 25 other locations)
Trial IDNCT06884631 on ClinicalTrials.gov

What this trial studies

This observational study aims to enhance the assessment of cardiovascular risk in patients with heart failure by utilizing the MECKI score, which integrates data from cardiopulmonary exercise testing (CPET) along with cardiac and kidney indexes. The study focuses on patients with left ventricular systolic dysfunction and stable clinical conditions, aiming to identify high-risk individuals through a comprehensive analysis of multiple prognostic factors. By incorporating ventilatory parameters and renal function into existing risk models, the study seeks to provide a more accurate risk estimation for heart failure patients.

Who should consider this trial

Good fit: Ideal candidates for this study are adults over 18 years old with a history of heart failure and documented left ventricular systolic dysfunction.

Not a fit: Patients with unstable clinical conditions or significant comorbidities that interfere with exercise performance may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to improved risk stratification and management of heart failure patients, potentially enhancing patient outcomes.

How similar studies have performed: Previous studies have shown promise in using combined prognostic models in heart failure, but the specific integration of the MECKI score represents a novel approach.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* age \>18 past or present heart failure (NYHA functional class I-III, stage C of the ACC/AHA classification)
* documentation of left ventricular systolic dysfunction (LVEF \<40%)
* stable clinical conditions
* previous or concomitant cardiopulmonary exercise test

Exclusion Criteria:

* scheduled cardiovascular treatment
* clinical unstable condition
* History of pulmonary embolism, significant valvular disease, pericardial disease, severe COPD, exercise-induced angina, exercise-induced ECG changes, severe brady- or tachyarrhythmias, or the presence of comorbidities that interfere with exercise performance.

Where this trial is running

Milan, Italy and 25 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Heart Failure, prognosis, risk score, heart failure, cardiopulmonary exercise test, exercise

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.