Identifying cancer predictors in high-risk lung cancer patients
Official title: Molecular Predictors of Lung Cancer Behavior
Run by Vanderbilt-Ingram Cancer Center · NCT00898313 · Data updated 2026-11-12
This study is trying to find out if certain biological markers in blood and other samples can help predict lung cancer in people who are at high risk.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 4000 (estimated) |
| Sponsor | Vanderbilt-Ingram Cancer Center Academic / other |
| Locations | 2 sites (Nashville, Tennessee and 1 other locations) |
| Status | Recruiting |
| Started | December 2003 |
| Main results expected | January 31, 2027 |
| Study ends | January 31, 2027 |
| Registry record updated | April 27, 2026 |
| Trial ID | NCT00898313 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults referred for evaluation of signs or symptoms of lung cancer at participating medical centers.
✕Probably not a fit
Patients who are unable to provide informed consent, minors, or pregnant women will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify molecular predictors of lung cancer in patients at high risk by analyzing various biological samples, including blood, urine, sputum, and lung tissue. The research focuses on evaluating DNA, RNA, and protein abnormalities in lung lesions using advanced techniques such as comparative genomic hybridization and proteomic profiling. By employing less invasive methods, the study seeks to improve the diagnosis and staging of both pre-invasive and invasive lung cancer lesions.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection and better management of lung cancer in high-risk patients.
How similar studies have gone: Other studies have shown promise in using molecular predictors for cancer diagnosis, making this approach both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: -All adults referred to Vanderbilt Medical Center, Veterans Administration Medical Center, St. Thomas Hospital and Meharry Medical Center for evaluation of signs or symptoms of lung cancer. Exclusion Criteria: * Inability to provide informed consent * Minors * Pregnant women
Where it's running
-
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States Recruiting -
Veterans Affairs Medical Center - Nashville
Nashville, Tennessee, United States Recruiting
Study contacts
- Study coordinator: Vanderbilt Ingram Clinical Trials Information Program
- Phone: 1-800-811-8480
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.