Clinical trial Recruiting at 2 sites Observational Ages 18 and up

Identifying cancer predictors in high-risk lung cancer patients

Official title: Molecular Predictors of Lung Cancer Behavior

Run by Vanderbilt-Ingram Cancer Center · NCT00898313 · Data updated 2026-11-12

This study is trying to find out if certain biological markers in blood and other samples can help predict lung cancer in people who are at high risk.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment4000 (estimated)
SponsorVanderbilt-Ingram Cancer Center
Academic / other
Locations2 sites (Nashville, Tennessee and 1 other locations)
StatusRecruiting
StartedDecember 2003
Main results expectedJanuary 31, 2027
Study endsJanuary 31, 2027
Registry record updatedApril 27, 2026
Trial IDNCT00898313 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults referred for evaluation of signs or symptoms of lung cancer at participating medical centers.

Probably not a fit

Patients who are unable to provide informed consent, minors, or pregnant women will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify molecular predictors of lung cancer in patients at high risk by analyzing various biological samples, including blood, urine, sputum, and lung tissue. The research focuses on evaluating DNA, RNA, and protein abnormalities in lung lesions using advanced techniques such as comparative genomic hybridization and proteomic profiling. By employing less invasive methods, the study seeks to improve the diagnosis and staging of both pre-invasive and invasive lung cancer lesions.

Why it matters

Potential benefit: If successful, this study could lead to earlier detection and better management of lung cancer in high-risk patients.

How similar studies have gone: Other studies have shown promise in using molecular predictors for cancer diagnosis, making this approach both relevant and potentially impactful.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

-All adults referred to Vanderbilt Medical Center, Veterans Administration Medical Center, St. Thomas Hospital and Meharry Medical Center for evaluation of signs or symptoms of lung cancer.

Exclusion Criteria:

* Inability to provide informed consent
* Minors
* Pregnant women

Where it's running

  • Vanderbilt-Ingram Cancer Center
    Nashville, Tennessee, United States
    Recruiting
  • Veterans Affairs Medical Center - Nashville
    Nashville, Tennessee, United States
    Recruiting

Study contacts

  • Study coordinator: Vanderbilt Ingram Clinical Trials Information Program
  • Phone: 1-800-811-8480

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.