Identifying brain lesions in multiple sclerosis using advanced MRI techniques
Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI: A Cross-sectional Study
Benha University · NCT06955832
This study is testing if a new type of MRI called PSIR can find early brain damage better than regular MRIs in people with Multiple Sclerosis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 15 Years to 65 Years |
| Sex | All |
| Sponsor | Benha University (other) |
| Locations | 3 sites (Banhā, Qalyubia Governorate and 2 other locations) |
| Trial ID | NCT06955832 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of Phase-Sensitive Inversion Recovery (PSIR) MRI in detecting early brain lesions in patients diagnosed with Multiple Sclerosis (MS). It will compare the diagnostic accuracy of PSIR MRI against conventional T2-weighted and Fluid Attenuated Inversion Recovery MRI sequences. Participants aged 15-65 years will be included based on the 2017 McDonald criteria for MS. The study hypothesizes that PSIR MRI will identify more cortical lesions and correlate better with clinical measures than traditional MRI methods.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 15-65 years who have been diagnosed with Multiple Sclerosis according to the McDonald criteria.
Not a fit: Patients with conditions such as stroke, previous intracranial hemorrhage, or those who cannot undergo MRI scans may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier and more accurate diagnosis of brain lesions in MS patients, potentially improving treatment outcomes.
How similar studies have performed: While the use of advanced MRI techniques in MS is a growing field, this specific approach using PSIR MRI for early lesion detection is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 15-65 years. * Both sexes. * Patients with MS according to McDonald Criterion Exclusion Criteria: * Age less than 15 years old. * Patients with stroke or previous intracranial hemorrhage. * Contraindications to MRI scans. * MS mimics.
Where this trial is running
Banhā, Qalyubia Governorate and 2 other locations
- Banha University Hospitals — Banhā, Qalyubia Governorate, Egypt (RECRUITING)
- El Mounira Multiple Sclerosis Unit — Cairo, Egypt (RECRUITING)
- Naser Institute MS Unit — Cairo, Egypt (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Multiple Sclerosis, Cortical lesions, MRI, Early diagnosis, McDonald criteria