Identifying biomarkers to predict sepsis outcomes
BIomarkers to Predict the Outcomes of Sepsis
This study is trying to find specific markers in the blood of sepsis patients that can help doctors predict how well they will recover.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Qilu Hospital of Shandong University Academic / other |
| Locations | 1 site (Ji'nan, Shandong) |
| Trial ID | NCT05842980 on ClinicalTrials.gov |
What this trial studies
This observational study aims to collect blood samples from patients diagnosed with sepsis or septic shock to identify biomarkers that can predict patient outcomes and prognosis. Sepsis is a critical condition characterized by organ dysfunction due to the body's immune response to infection, and its diagnosis is often complicated by high variability among patients. By analyzing these blood samples, researchers hope to uncover specific biomarkers that can help in assessing the severity of sepsis and guiding treatment decisions. The findings could lead to improved management strategies for sepsis patients, ultimately enhancing their chances of recovery.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 85 who meet the diagnostic criteria for sepsis or septic shock.
Not a fit: Patients with autoimmune diseases, severe chronic illnesses, or those currently receiving glucocorticoid treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better prediction of sepsis outcomes, allowing for more tailored and effective treatments for patients.
How similar studies have performed: Other studies have explored biomarkers in sepsis, showing promise in improving diagnosis and treatment, but this specific approach may offer novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: - The clinical diagnostic criteria for sepsis or septic shock that comply with the 3rd edition of the International Consensus on Sepsis and Sepsis Shock (Sepsis-3.0) are: 1. Sepsis-3.0 sepsis diagnosis criteria: infection or suspected infection with a Sequential Organ Failure Score (SOFA score) ≥ 2 points; 2. Sepsis-3.0 diagnostic criteria for septic shock: Sepsis with persistent hypotension, after sufficient fluid resuscitation, still requires vasopressor drugs to maintain average arterial pressure ≥ 65mmHg, and serum lactate level\>2mmol/L (18mg/dL). 3. Age 18 to 85 years old Exclusion Criteria: 1. patients with autoimmune disease, acquired immunodeficiency syndrome, agranulocytosis (\<0.5 × 109/L), malignant tumors or other serious chronic diseases (heart failure, Liver failure, end-stage renal disease, etc.); 2. Receiving glucocorticoid treatment; 3. Pregnancy; 4. Refuse enrollment or give up active treatment. -
Where this trial is running
Ji'nan, Shandong
- Qilu Hospital of Shandong University — Ji'nan, Shandong, China (Recruiting)
Study contacts
- Study coordinator: Jiaojiao Pang, Dr
- Email: jiaojiaopang@126.com
- Phone: 18560089129
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.