Identifying biomarkers in lung cancer patients in Malaysia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify biomarkers and signatures that can differentiate between high-risk individuals and lung cancer patients. It focuses on discovering blood-based biomarkers that serve as adjunct tests to imaging diagnoses, thereby improving patient follow-up. The study hypothesizes that changes in cell-free DNA and RNA expression during disease progression can yield valuable biomarker signatures. Participants will provide blood samples and imaging results to facilitate this research.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female subjects aged 30 and above.
* No previous history of any cancers.
* Able to provide X-ray and/or LDCT results.
* Have either COPD or pulmonary nodules measuring less than 11mm, or deemed not for biopsy by attending physician
* Willing to go back for a follow-up X-ray or LDCT scan in the next clinical follow up as per standard of care.
* Willing to provide up to 30mL of blood in month-0 (first visit) and up to 21mL in the next standard of care follow up visit (second visit).

Exclusion Criteria:

* Subject has received chemotherapy or radiotherapy for cancer treatment, and any other cancer-related treatment.
* Subject is pregnant or lactating (self-declaration).
* Subject is unwilling or unable to provide signed informed consent

Where it's running

• University of Malaya Medical Centre
  Kuala Lumpur, Malaysia Recruiting

Study contacts

• Principal investigator: Mau Ern Poh — University of Malaya
• Study coordinator: Mau Ern Poh
• Email: ernestpoh@gmail.com
• Phone: +60379494422

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.