Identifying biomarkers for urinary stone recurrence
Exploring Multiomics Biomarkers for Urolithiasis
This study is trying to find specific markers in urine that can help tell if people are likely to get kidney stones again, by comparing those who have had stones before to those who haven't.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Shatin) |
| Trial ID | NCT05452291 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze urine samples from 100 Chinese patients with a history of recurrent urinary stones and a control group of non-stone formers. By employing a multiomics approach, including metabolomics and proteomics, the study seeks to identify potential biomarkers that differentiate between recurrent stone formers and those without a history of stones. Following initial analysis, a larger cohort of 1000 patients will be validated over a three-year follow-up period to assess stone recurrence through clinical evaluations and imaging. The ultimate goal is to correlate identified biomarkers with clinical outcomes related to stone recurrence.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with a history of recurrent urinary stones.
Not a fit: Patients with active urinary infections or those with radiolucent stones may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the development of predictive biomarkers that help prevent urinary stone recurrence in patients.
How similar studies have performed: While the multiomics approach is gaining traction, this specific study's focus on urinary stone recurrence is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with history of recurrent urinary stone * Age greater than or equal to 18 years old * Have more than 2 episodes of radio-opaque stone disease (bilateral stones were counted as two episode) Patients with no history of urinary stone disease * Age greater than or equal to 18 years old * With no history of urinary calculi, from history and imaging. Exclusion criteria: * Patient refused or unable to provide consent for the study * Patient with active urinary infection * Patient with radiolucent stone or infective stone * Patients with no history of urinary stone disease (for control group) * Patient refused or unable to provide consent for the study * Patient with active urinary infection
Where this trial is running
Shatin
- Prince of Wales Hospital — Shatin, Hong Kong (Recruiting)
Study contacts
- Principal investigator: Chi Fai NG, MD — Chinese University of Hong Kong
- Study coordinator: Chi Fai NG, MD
- Email: ngcf@surgery.cuhk.edu.hk
- Phone: 35052625
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.