Clinical trial Recruiting at 1 site Observational Ages 21 to 99

Identifying biomarkers for radiation sensitivity in cancer patients

Official title: Discovery of Biomarkers for Intrinsic Radiation Sensitivity in Cancer Patients

Run by National Cancer Centre, Singapore · NCT04340024 · Data updated 2026-11-12

This study is trying to find out if certain blood and tissue markers can help predict how sensitive cancer patients are to radiation therapy, especially those who have had bad side effects.

Quick facts

Study typeObservational
Ages21 Years to 99 Years
SexAll
Enrollment5000 (estimated)
SponsorNational Cancer Centre, Singapore
Academic / other
Drugs / interventionsradiation
Locations1 site (Singapore)
StatusRecruiting
StartedSeptember 30, 2015
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedJune 11, 2025
Trial IDNCT04340024 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 21 to 98 who have experienced severe side effects from radiotherapy or have cancers known to be sensitive to radiation.

Probably not a fit

Patients outside the age range of 21 to 98 or those without severe side effects from radiotherapy may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to recruit patients with nasopharyngeal cancer, prostate cancer, or other cancers that are sensitive to radiotherapy, particularly those who have experienced severe side effects from such treatments. Blood and matched tumor-normal tissue samples will be collected from participants to analyze genetic and biochemical markers. The goal is to identify biomarkers that could predict individual sensitivity to radiation therapy, enhancing personalized treatment approaches in oncology.

Why it matters

Potential benefit: If successful, this research could lead to more tailored radiotherapy treatments, minimizing side effects and improving outcomes for cancer patients.

How similar studies have gone: While the approach of identifying biomarkers for radiation sensitivity is being explored in various contexts, this specific study focuses on a novel combination of genomics and immunomics in the context of radiotherapy.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients with severe side effects from radiotherapy
* Patients with a type of cancer that is associated with sensitivity to radiotherapy

Exclusion Criteria:

* Age of patient must be between 21 (inclusive) and 99 (exclusive)

Where it's running

  • National Cancer Center Singapore
    Singapore, Singapore
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.