Identifying biomarkers for ocular disorders related to neurovascular issues
Recherche de Biomarqueurs moléculaires et d'Imagerie Diagnostiques et Pronostiques Des Atteintes Oculaires associées à Des dérégulations Neurovasculaires : Cohorte Biocor
This study is trying to find specific biological markers linked to eye conditions like ocular rosacea and pachychoroid disease to help develop better treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Clinact Academic / other |
| Locations | 1 site (Paris) |
| Trial ID | NCT06466018 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to identify molecular biomarkers associated with ocular rosacea and pachychoroid disease. It will utilize imaging techniques such as OCT and autofluorescence to correlate specific ocular conditions with biological markers derived from preclinical studies and advanced methods like proteomics and metabolomics. The study will also explore circulating and functional biomarkers to determine potential treatments that target autonomic nervous system regulation and mineralocorticoid pathways. Participants will undergo assessments including the Schirmer test to evaluate tear production.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 of European descent with clear ocular media for imaging and who have provided informed consent.
Not a fit: Patients with high myopia, diabetic retinopathy, or other specified ocular conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment options for patients with ocular rosacea and pachychoroid disease.
How similar studies have performed: While similar studies have explored biomarkers in ocular conditions, this specific approach focusing on neurovascular deregulation is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female \> 18 years of age, of European origin, with signed ± genetic consent * Clear ocular media for OCT and autofluorescence imaging * Signed consent form * Be affiliated to a health insurance scheme * Control patients are patients scheduled for cataract surgery or visual assessment. Exclusion Criteria: * High myopia \> 6D * Diabetic retinopathy, hereditary retinal dystrophy, untreated retinal detachment, choroidal ocular tumor, choroidal hemangioma * Epithelial or stromal keratopathy other than ocular rosacea * Corneal surgery less than 3 months old, keratoplasty * Deprived of liberty or under guardianship or curatorship
Where this trial is running
Paris
- Departement of Ophthalmology, COCHIN Hospital — Paris, France (Recruiting)
Study contacts
- Study coordinator: Cra
- Email: contact@multihealthgroup.com
- Phone: + 3315 841 28 98
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.