Identifying Bacteria in Atherosclerotic Plaques and Their Risk Factors

Ultrastructural Pathology and Pathophysiology of Atherosclerotic Plague With Intracellular Bactria

This study is trying to find out what types of bacteria are in the plaque of arteries in people with atherosclerosis and how these bacteria might affect their health after surgery.

Quick facts

• Study type: Observational
• Enrollment: 200 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Tang-Du Hospital (Academic / other)
• Locations: 1 site (Xian, Shanxi)
• Trial ID: NCT06935279 on ClinicalTrials.gov

What this trial studies

This observational study aims to identify the types of intracellular bacteria present in carotid plaques of patients with atherosclerosis and analyze associated risk factors. Researchers will examine the presence and diversity of these bacteria in patients with varying degrees of carotid artery stenosis and assess their impact on patient prognosis. The study will involve collecting data from patients who have undergone carotid endarterectomy, monitoring their clinical outcomes, and performing laboratory analyses to establish correlations between bacterial presence and postoperative complications.

Who should consider this trial

Good fit: Ideal candidates for this study are patients diagnosed with carotid artery stenosis who have experienced symptomatic or asymptomatic risk events after head and neck revascularization.

Not a fit: Patients without carotid artery stenosis or those who have not undergone head and neck vascular procedures may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding of how intracellular bacteria influence the prognosis of patients with carotid artery stenosis, potentially guiding more effective treatment strategies.

How similar studies have performed: While the specific focus on intracellular bacteria in carotid plaques is novel, similar studies have shown that understanding bacterial presence in vascular conditions can provide insights into patient outcomes.

Eligibility criteria

Inclusion Criteria:

* All enrolled patients were diagnosed with clear head and neck artery stenosis and a risk event after head and neck revascularization;
* Location of lesion: origin of internal carotid artery, bifurcation of internal and external carotid arteries;
* Patients with symptomatic head and neck artery stenosis and dangerous events after head and neck blood flow reconstruction, and with a degree of stenosis ≥ 70% on non-invasive examination or stenosis ≥ 50% found on angiography;
* Asymptomatic head and neck artery stenosis and risk events after head and neck revascularization, with a degree of stenosis ≥ 70% on non-invasive examination or stenosis ≥ 60% found on angiography;
* Asymptomatic head and neck artery stenosis and dangerous events after head and neck blood flow reconstruction, with a non-invasive examination of stenosis degree less than 70%, but angiography or other examinations indicate that the stenosis lesion is in an unstable state;
* Symptomatic head and neck artery stenosis and risk events after head and neck revascularization, non-invasive examination of head and neck artery stenosis and risk event degree after head and neck revascularization at 50% to 69%

Exclusion Criteria:

* Patients with poor overall condition and intolerance to general anesthesia;
* Patients with mental illness or severe mental illness;
* Severe respiratory system diseases;
* Pregnant and lactating women;
* Participating in another clinical study;
* Patients with advanced tumors or those who are expected to die within one year;

Where this trial is running

Xian, Shanxi

• Tangdu Hospital — Xian, Shanxi, China (Recruiting)

Conditions Carotid Artery Stenosis; Carotid Artery Stenosis Asymptomatic; Carotid Artery Stenosis Symptomatic; Cerebral Infarction; Transient Ischemic Attack; Hypertension and Cardiovascular Risk Factors; Hypertension, Essential; Diabetes