Identifying a brain activity marker for blood vessel reopening in stroke patients
Search for a Recanalization of the Sylvian Artery Electro-Physiological Biomarker
Fondation Ophtalmologique Adolphe de Rothschild · NCT05473975
This study is testing if brain activity measured by EEG can help doctors see if blood vessels are reopening in stroke patients during treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 15 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild (network) |
| Locations | 1 site (Paris) |
| Trial ID | NCT05473975 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify an electroencephalographic (EEG) biomarker that indicates successful recanalization of the sylvian artery in patients experiencing acute ischemic stroke (AIS). The study will monitor patients undergoing thrombectomy to validate the EEG biomarker in real-time during the procedure. By establishing a correlation between the EEG readings and recanalization, the research seeks to improve the assessment of treatment efficacy during intravenous thrombolysis in future studies.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who have a cerebral infarction with proximal occlusion of the sylvian artery and require thrombectomy.
Not a fit: Patients who are pregnant, breastfeeding, or have had recent cranial surgery that prevents EEG placement may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a non-invasive method to monitor and validate treatment effectiveness in stroke patients, potentially improving outcomes.
How similar studies have performed: While the approach of using EEG biomarkers in this context is innovative, similar studies have not been widely reported, indicating this may be a novel exploration.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient over 18 years old * Presenting a cerebral infarction with proximal occlusion of the sylvian artery requiring thrombectomy * No objection to participation in the study Exclusion Criteria: * Pregnant or breastfeeding women * Patient benefiting from legal protection * Absence of affiliation to a social protection scheme * Recent cranial surgery not allowing the installation of a scalp EEG
Where this trial is running
Paris
- Fondation Ophtalmologique A. de Rothschild — Paris, France (RECRUITING)
Study contacts
- Principal investigator: Michael OBADIA — HOPITAL FONDATION Adolphe de ROTHSCHILD
- Study coordinator: Amélie YAVCHITZ
- Email: ayavhitz@for.paris
- Phone: 01 48 03 64 54
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: AIS