Identifying a Blood Test to Predict Female Infertility
Looking for a Blood Epigenetic Signature to Predict Female Infertility
This study is testing a blood test to see if it can predict infertility in women by looking at changes in their DNA.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1456 (estimated) |
| Ages | 18 Years to 43 Years |
| Sex | Female |
| Sponsor | Università Vita-Salute San Raffaele Academic / other |
| Locations | 1 site (Milan) |
| Trial ID | NCT06098495 on ClinicalTrials.gov |
What this trial studies
This research project investigates the DNA methylation mechanisms that contribute to reduced fertility due to declining oocyte quality. The goal is to develop an epigenetic clock for mature germ cells (MGCs) by analyzing blood samples, ensuring a non-invasive approach that can be clinically applicable. The study will explore various aspects of female infertility through multiple studies conducted in different settings to identify a specific blood epigenetic signature that can predict infertility outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 18 to 43 who are experiencing infertility and undergoing assisted reproductive technology (ART) or have a history of recurrent pregnancy loss.
Not a fit: Patients under 18 or over 44, those with previous ovarian surgery, or severe male factor infertility may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a reliable blood test for predicting female infertility, aiding in early diagnosis and treatment.
How similar studies have performed: While the approach of using blood epigenetic signatures for predicting infertility is innovative, similar studies have shown promise in other areas of reproductive health.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18\< age \<43, Infertile woman undergoing ART, recurrent pregnancy loss Exclusion Criteria: * age \< 18 or \> 44, previous ovarian surgery, severe male factor infertility
Where this trial is running
Milan
- Università Vita Salute San Raffaele — Milan, Italy (Recruiting)
Study contacts
- Study coordinator: Valeria Stella Vanni
- Email: vanni.valeria@hsr.it
- Phone: +393476309895
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.