ICOPE INTENSE-K program to improve mobility, thinking, and immune health in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a pilot interventional program testing a very intensive version of the WHO ICOPE nonpharmacological care model alongside ketone ester supplementation compared with placebo, with vitamin D3 and omega‑3 provided per protocol. Participants are community-dwelling older adults with mobility impairment, sedentary behavior, mild cognitive impairment on ICOPE/MMSE screening, and BMI ≥25. The study measures changes in key aging functions — mobility (chair‑rise), cognition, and biomarkers linked to immunosenescence — to estimate maximum effect sizes achievable with nonpharmacological care and ketone support. Results are intended to provide reference data for future geroscience trials and for comparing new gerotherapeutic drugs against a strong behavioral benchmark.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Independent-living (ADL ≥5/6)
* Men and women
* Mobility impairment (5 Chair-rise test \>12 seconds)
* Sedentarism (spend six or more hours per day sitting or lying down)
* Positive screening for cognitive impairment according to the ICOPE screening tool with MMSE \[25-28\]
* BMI ≥25 kg/m2

Exclusion Criteria:

* Unintentional weight loss (≥10%) in past 6 months
* Dementia
* Life-threatening illnesses, with a life expectancy (judged by the investigating doctor) of less than 1 year
* Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina or any other contraindication to physical activity (as determined by a physician) or comorbid disease that would impair ability to participate in the ICOPE intense intervention such as renal failure on hemodialysis, severe psychiatric disorder (depressive participant will not be excluded)
* Organizational inability (three-time per week during the 60 days)
* Living in a Nursing-Home
* Under legal protection measure (guardianship, curatorship, safeguard of justice

Where it's running

• Cité de la santé - Hopital La Grave
  Toulouse, France Recruiting

Study contacts

• Study coordinator: Yves ROLLAND
• Email: rolland.y@chu-toulouse.fr
• Phone: 0534557607

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Muscle function response to resistance-band training in older adults with low muscle power

  This study tests whether resistance-band exercise plus fitness advice can improve balance and muscle power in older adults with weak leg power.

  Recruiting Brunel University · London · NCT07672834

• L‑serine supplements with or without strength training for older adults

  This trial tries daily L‑serine supplements, alone or combined with supervised strength training, to see if they improve thinking, brain health, and physical fitness in healthy 65–85‑year‑olds.

  Recruiting University of Vienna · Vienna, State of Vienna · NCT07466290

• Personalized 8-week program to support healthier aging with exercise, lifestyle coaching, and targeted supplements

  This program will try a personalized 8-week mix of supervised exercise, sleep and diet coaching, motivational support, and supplements (whey protein, creatine, NMN, fucoidan, multivitamin) for adults aged 50–80 with below-average fitness or cognitive scores.

  Recruiting National University of Singapore · Singapore, Singapore · NCT07451496

• HMB and 2-HOBA to Support Muscle Strength and Thinking in Adults 65+

  This study tests whether taking HMB, 2-HOBA, or both can improve muscle strength and cognitive function in adults over 65.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT07419633

• Survey on disability and cognitive impairment in elderly people in Beijing

  This study is trying to find out what factors might lead to disability and memory problems in older adults living in Beijing, so they can help prevent these issues in the future.

  Recruiting Xuanwu Hospital, Beijing · Beijing · NCT06863727

• Oral vitamin C to promote health in middle-aged and older adults

  This trial will test whether taking oral vitamin C daily for 12 months can slow aging-related changes in generally healthy people aged 55–65.

  Recruiting at 2 sites Peking University Third Hospital · Nanchang, Jiangxi and 2 other locations · NCT06794255

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.