Hyperbaric oxygen therapy for men with low sperm count
Hyperbaric Oxygen Therapy for Men Suffering From Infertility Due to Oligospermia: a Pilot Study
This study is testing if hyperbaric oxygen therapy can help men with low sperm count improve their fertility.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 21 Years and up |
| Sex | Male |
| Sponsor | Assaf-Harofeh Medical Center Government |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Ẕerifin) |
| Trial ID | NCT05842239 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of hyperbaric oxygen therapy (HBOT) on men suffering from infertility due to oligospermia, which is characterized by a low sperm count. The research aims to determine whether HBOT can improve sperm count by enhancing mitochondrial function and telomere length, both of which are crucial for sperm health. Eligible participants will undergo HBOT and their sperm quality will be assessed through multiple examinations. The study seeks to provide insights into a potential new treatment for male infertility.
Who should consider this trial
Good fit: Ideal candidates for this study are men over 21 years old who have been diagnosed with idiopathic oligospermia and have had at least two sperm examinations showing low sperm counts.
Not a fit: Patients with active malignancies, severe chronic diseases, or those who have previously undergone hyperbaric oxygen therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this therapy could significantly improve fertility outcomes for men with oligospermia.
How similar studies have performed: While the application of HBOT for infertility is relatively novel, preliminary studies suggest potential benefits, though more research is needed to establish its efficacy.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age above 21 years 2. At least two sperm examination showing oligospermia (\<15·106 sperm/mL) 3. Diagnosis of idiopathic oligospermia. 4. Subject willing and able to read, understand and sign an informed consent Exclusion Criteria: 1. Inability to attend scheduled clinic visits and/or comply with the study protocol 2. Active malignancy 3. Previous treatment with chemotherapy and/or radiation therapy 4. Substance use at baseline 5. Severe or unstable physical disorders or major cognitive deficits at baseline 6. HBOT for any reason prior to study enrolment 7. Chest pathology incompatible with pressure changes (including moderate to severe asthma) 8. Ear or Sinus pathology incompatible with pressure changes 9. Chronic disease like diabetes mellitus, ischemic heart disease etc. 10. Active smoking
Where this trial is running
Ẕerifin
- The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center (Assaf Harofeh) — Ẕerifin, Israel (Recruiting)
Study contacts
- Principal investigator: Shachar Finci, MD — Asaf-Harofhe MC
- Study coordinator: Shachar Finci, MD
- Email: shacharf@shamir.gov.il
- Phone: 97289542395
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.