Hyperbaric oxygen therapy for men with low sperm count

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of hyperbaric oxygen therapy (HBOT) on men suffering from infertility due to oligospermia, which is characterized by a low sperm count. The research aims to determine whether HBOT can improve sperm count by enhancing mitochondrial function and telomere length, both of which are crucial for sperm health. Eligible participants will undergo HBOT and their sperm quality will be assessed through multiple examinations. The study seeks to provide insights into a potential new treatment for male infertility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age above 21 years
2. At least two sperm examination showing oligospermia (\<15·106 sperm/mL)
3. Diagnosis of idiopathic oligospermia.
4. Subject willing and able to read, understand and sign an informed consent

Exclusion Criteria:

1. Inability to attend scheduled clinic visits and/or comply with the study protocol
2. Active malignancy
3. Previous treatment with chemotherapy and/or radiation therapy
4. Substance use at baseline
5. Severe or unstable physical disorders or major cognitive deficits at baseline
6. HBOT for any reason prior to study enrolment
7. Chest pathology incompatible with pressure changes (including moderate to severe asthma)
8. Ear or Sinus pathology incompatible with pressure changes
9. Chronic disease like diabetes mellitus, ischemic heart disease etc.
10. Active smoking

Where it's running

• The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center (Assaf Harofeh)
  Tsrifin, Israel Recruiting

Study contacts

• Principal investigator: Shachar Finci, MD — Asaf-Harofhe MC
• Study coordinator: Shachar Finci, MD
• Email: shacharf@shamir.gov.il
• Phone: 97289542395

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Identifying genetic variants in non-obstructive azoospermia and primary ovarian insufficiency

  This project will collect DNA from adults with NOA, oligospermia, or POI to try to find gene changes that may cause their infertility.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 1 other locations · NCT07357701

• Treatment for severe male infertility using MediReg®

  This study is testing a new treatment called MediReg® to see if it can help men with severe infertility issues improve their sperm quality and increase their chances of conceiving.

  Recruiting Phase 1/2 Lomonosov Moscow State University Medical Research and Educational Center · Moscow, Moscow · NCT06869863

• Efficacy and safety of Tribulus terrestris products for men with low sperm count

  This study tests if a natural supplement from Tribulus terrestris can help men with low sperm count improve their condition safely.

  Recruiting Phase 4 Herbarium Laboratorio Botanico Ltda · Valinhos, São Paulo · NCT06260007

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.