Hyperbaric oxygen at 1.75 ATA to boost VO2‑max and lower inflammation in adults 30–60
Official title: The Effects of Hyperbaric Oxygen Therapy at Intermediate Pressure (1.75 ATA) on VO₂ Max and Inflammatory Cytokine Profiles
Run by University of Texas at Austin · NCT07361861 · Data updated 2026-11-12
This study will test whether breathing pure oxygen under 1.75 ATA pressure can raise VO2‑max and lower inflammation markers in healthy adults aged 30–60.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 30 Years to 60 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Texas at Austin Academic / other |
| Locations | 2 sites (Austin, Texas and 1 other locations) |
| Status | Recruiting |
| Started | January 2026 |
| Main results expected | May 2026 |
| Study ends | July 2026 |
| Registry record updated | January 23, 2026 |
| Trial ID | NCT07361861 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are physically active adults aged 30–60 without chronic illnesses and without HBOT exposure in the prior three months who can tolerate a pressurized chamber.
✕Probably not a fit
People with contraindications to HBOT—such as certain lung diseases, severe claustrophobia, or other medical exclusions—are unlikely to benefit and are not eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study delivers hyperbaric oxygen therapy (HBOT) at 1.75 atmospheres absolute in a pressurized chamber to physically active adults aged 30–60 with no chronic illnesses. Participants will have baseline and follow-up VO2‑max testing and blood draws to measure a panel of inflammatory cytokines before and after the HBOT course. The protocol targets a pressure that prior research suggests may alter cytokine profiles differently than lower or higher pressures, and HBOT is investigational for improving fitness outcomes. Safety screening excludes standard HBOT contraindications such as certain lung diseases and severe claustrophobia.
Why it matters
Potential benefit: If successful, the intervention could increase aerobic fitness and reduce systemic inflammation markers in healthy adults, potentially improving cardiovascular health and recovery.
How similar studies have gone: Some prior research shows pressure-dependent effects of HBOT on inflammatory cytokines, but clear evidence that HBOT improves VO2‑max in healthy adults is limited and the approach remains relatively novel for this outcome.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * physically active individuals with no history of chronic illness or HBOT exposure within the last three months. Exclusion Criteria: * individuals with contraindications to HBOT, including lung diseases or claustrophobia.
Where it's running
-
ATX Hyperbarics
Austin, Texas, United States Recruiting -
Westlake Medical Arts
Austin, Texas, United States Active not recruiting
Study contacts
- Study coordinator: Emma Lehrer, BSA Biology
- Email: elehrer@utexas.edu
- Phone: 7379321934
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.