Hydrogen inhalation to reduce post-operative pain and inflammation
The Effect of Perioperative Hydrogen Inhalation on Post-operative Pain and Inflammation Cytokines
NA · Fu Jen Catholic University Hospital · NCT05476575
This study is testing if inhaling a small amount of hydrogen gas can help reduce pain and inflammation after surgery for herniated discs.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 64 (estimated) |
| Ages | 20 Years to 75 Years |
| Sex | All |
| Sponsor | Fu Jen Catholic University Hospital (other) |
| Locations | 1 site (New Taipei City) |
| Trial ID | NCT05476575 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of inhaling hydrogen gas during the perioperative period on post-operative pain and inflammation markers in patients undergoing endoscopic discectomy for herniated discs. The intervention involves administering a low concentration of hydrogen (4%) via nasal cannula, which has shown potential therapeutic effects in reducing inflammation and pain. The study aims to evaluate whether this method can improve recovery outcomes by decreasing pain levels and inflammatory cytokines in the serum post-surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 20 to 75 with herniated discs causing severe neuropathic pain that has not responded to conservative treatments.
Not a fit: Patients with severe comorbidities, those under 20 or over 75 years old, or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance pain management and recovery for patients undergoing surgery.
How similar studies have performed: While the use of hydrogen inhalation is a novel approach, previous studies have indicated its potential benefits in reducing inflammation and improving outcomes in various medical conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with herniated disc leading to severe neuropathic pain refractory to conservative treatment, receiving endoscopic discectomy. Exclusion Criteria: * American Society of Anesthesiologists class IV or above * Sever impairment of heart, lung, kidney and liver and autoimmune disease * Less than 20 years old or older than 75 years old * Patient refusal * Severe complication occurring perioperatively * Current pregnancy * Hemoglobin less than 10g/dL.
Where this trial is running
New Taipei City
- Fu Jen Catholic University Hospital — New Taipei City, Taiwan (RECRUITING)
Study contacts
- Study coordinator: Chao Hsien Sung, MD
- Email: joe411002@gmail.com
- Phone: +886-912072103
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Pain, Acute, pain, hydrogen inhalation, discectomy